{"id":"W2023459278","doi":"10.1073/pnas.0700477104","title":"Soluble misfolded subfractions of mutant superoxide dismutase-1s are enriched in spinal cords throughout life in murine ALS models","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Neuroförbundet; Svenska Läkaresällskapet; Ludwig Institute for Cancer Research","keywords":"SOD1; Mutant; Superoxide dismutase; Chemistry; Biochemistry; Superoxide; Cytotoxicity; Dismutase; Cell biology; Protein folding; In vivo; Molecular biology; Biology; In vitro; Enzyme; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002180422,0.0005010238,0.0003042827,0.0008952009,0.0002251646,0.0002921993,0.000231156,0.0003015306,0.0009179588],"category_scores_gemma":[0.0001345637,0.0002495178,0.0002314674,0.0003246763,0.0002910061,0.0002260469,0.0003399923,0.0007428554,0.000302321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002791923,"about_ca_system_score_gemma":0.0001406062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003743996,"about_ca_topic_score_gemma":0.0007223196,"domain_scores_codex":[0.9996617,0.00002920879,0.00004321739,0.000101127,0.00009509463,0.00006958997],"domain_scores_gemma":[0.9996707,0.00001854743,0.0001030866,0.00002880806,0.00005041758,0.0001284716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009648666,0.00001507963,0.0004535836,0.00002393635,0.000009062402,0.0000361416,0.00003811104,0.0000169817,0.9988081,0.00002695824,0.00001823226,0.0004573227],"study_design_scores_gemma":[0.000009466806,0.0004800742,0.04568705,0.00001850054,0.00006027108,0.0007528861,0.00008859925,0.0008207712,0.9499623,0.0001062061,0.002003295,0.00001057582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914119,0.002253611,0.004669643,0.0001008978,0.00003114401,0.00004745911,0.0006985835,0.0001339537,0.0006527384],"genre_scores_gemma":[0.987473,0.001202797,0.005166363,0.00009845671,0.00001692121,0.0000973948,0.00177035,0.00006862658,0.004105884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009179588,"threshold_uncertainty_score":0.003070891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1131934129445616,"score_gpt":0.3894828602258427,"score_spread":0.276289447281281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}