{"id":"W2023473560","doi":"10.1002/ijc.23470","title":"LINE‐1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer","year":2008,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":263,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Gary Bennett Family Fund","keywords":"Microsatellite instability; MLH1; DNA methylation; Methylation; Biology; CDKN2A; CpG site; Cancer research; Population; Colorectal cancer; Genetics; Cancer; Molecular biology; DNA mismatch repair; Microsatellite; Medicine; Gene; Gene expression; Allele","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002810948,0.0001655248,0.0003643282,0.0002662732,0.00003422629,0.00001996597,0.0001340508,0.0001191953,0.0005327725],"category_scores_gemma":[0.0002388673,0.0001297362,0.0000750376,0.0002750739,0.0001862331,0.0001761811,0.00003547865,0.0003694768,0.000001479573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008443503,"about_ca_system_score_gemma":0.0007692454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006548311,"about_ca_topic_score_gemma":0.002357876,"domain_scores_codex":[0.9983733,0.00005035636,0.0004904365,0.0002031285,0.0007042655,0.0001785565],"domain_scores_gemma":[0.9981527,0.0001492023,0.0004069466,0.00006746367,0.001101881,0.0001217986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00251146,0.000149424,0.9593328,0.00001718308,0.0005846661,0.00008283425,0.001877927,0.0005137244,0.02474249,0.000008957392,0.0003876739,0.009790835],"study_design_scores_gemma":[0.004432524,0.0004826318,0.9382073,0.0003376573,0.0001071442,0.0001134984,0.00005066796,0.0003354798,0.05377004,0.0001591915,0.001839377,0.0001645306],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919685,0.005386844,0.00007209436,0.001306647,0.0007601055,0.0001873371,0.00009030513,0.000008288108,0.000219931],"genre_scores_gemma":[0.9958422,0.002660915,0.000436357,0.0006428699,0.0002941716,0.00002198729,0.000005780632,0.00002160219,0.00007411191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02902755,"threshold_uncertainty_score":0.5833485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02677388218629012,"score_gpt":0.310441537477681,"score_spread":0.2836676552913909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}