{"id":"W2023529914","doi":"10.1074/jbc.m410722200","title":"The Structural and Dynamic Basis of Ets-1 DNA Binding Autoinhibition","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; Government of Canada; National Institutes of Health; Huntsman Cancer Institute","keywords":"Chemistry; Allosteric regulation; Biophysics; DNA; Molecular dynamics; Dimer; Helix (gastropod); Intramolecular force; Intermolecular force; Hydrogen bond; Crystallography; Nuclear magnetic resonance spectroscopy; DNA-binding domain; Stereochemistry; Binding site; Transcription factor; Biochemistry; Molecule; Biology; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008020999,0.0001198305,0.0001004792,0.00007056878,0.0001179832,0.0001294678,0.0002133781,0.0001527744,0.0006354701],"category_scores_gemma":[0.0001757598,0.0001035637,0.0000779052,0.0000582836,0.0001851968,0.0001809085,0.0001082813,0.0002520187,0.0001560506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003300463,"about_ca_system_score_gemma":0.0001498776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007174381,"about_ca_topic_score_gemma":0.0007715189,"domain_scores_codex":[0.9999566,0.000004802795,0.000001972086,0.0000119389,0.00001527583,0.00000941393],"domain_scores_gemma":[0.9999346,0.0000170415,0.00002105057,0.000005523739,0.000006948841,0.00001483756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009814918,0.00002189152,0.001111023,0.00002495227,0.000003545023,0.00006890369,0.00002671736,0.001293039,0.9950277,0.0006125258,0.00003862081,0.001673],"study_design_scores_gemma":[0.00003916071,0.0002781186,0.09861717,0.00001753137,0.00002430009,0.0008262047,0.0001504546,0.06079576,0.8339154,0.002488018,0.002812426,0.00003541322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978668,0.0003331743,0.0008666023,0.00004840859,0.000003469295,0.000003030565,0.0000556478,0.00001963254,0.000803274],"genre_scores_gemma":[0.9992654,0.000110209,0.0002735341,0.00001488605,0.000002699921,0.000003962462,0.0001139494,0.000004177513,0.0002112471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007174381,"threshold_uncertainty_score":0.002394676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077618488575735,"score_gpt":0.2403945701527944,"score_spread":0.229618385267037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}