{"id":"W2023529914","doi":"10.1074/jbc.m410722200","title":"The Structural and Dynamic Basis of Ets-1 DNA Binding Autoinhibition","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; Government of Canada; National Institutes of Health; Huntsman Cancer Institute","keywords":"Chemistry; Allosteric regulation; Biophysics; DNA; Molecular dynamics; Dimer; Helix (gastropod); Intramolecular force; Intermolecular force; Hydrogen bond; Crystallography; Nuclear magnetic resonance spectroscopy; DNA-binding domain; Stereochemistry; Binding site; Transcription factor; Biochemistry; Molecule; Biology; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003079954,0.00006923413,0.0001335173,0.00001027954,0.00009805769,0.00002614232,0.0001025298,0.00009339255,0.0001988549],"category_scores_gemma":[0.0001411885,0.00003440005,0.00005815873,0.00004403825,0.0001458576,0.00007688352,0.00002999192,0.0001326613,0.000001503846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003355218,"about_ca_system_score_gemma":0.0000162634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.387098e-7,"about_ca_topic_score_gemma":7.847154e-7,"domain_scores_codex":[0.999371,0.0000254564,0.0002937955,0.0000799015,0.0001211421,0.0001087332],"domain_scores_gemma":[0.9994293,0.00009729003,0.0003030705,0.00006331741,0.00006376624,0.00004329225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004788363,0.000003824842,0.0003520917,0.000008776031,0.000004445931,0.000001379482,0.00001805856,0.000007747083,0.9962694,0.00002120608,0.00008674113,0.00317846],"study_design_scores_gemma":[0.0001882302,0.000071471,0.004940589,0.00002017343,0.000009867707,0.0001930784,0.00008925561,0.000076456,0.9932671,0.0005565723,0.0005369391,0.00005023515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987512,0.0003368673,0.00004083309,0.0004292721,0.0001165973,0.00001764119,0.000007354883,0.000006522531,0.000293694],"genre_scores_gemma":[0.9989828,0.000091553,0.0006466078,0.00003110078,0.0001941177,3.176713e-7,0.000001639475,0.000002246634,0.00004959905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004588497,"threshold_uncertainty_score":0.2177322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077618488575735,"score_gpt":0.2403945701527944,"score_spread":0.229618385267037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}