{"id":"W2023582466","doi":"10.1074/jbc.m406810200","title":"Enzymatic Characterization and Homology Model of a Catalytically Active Recombinant West Nile Virus NS3 Protease","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"NS3; Flavivirus; Virology; Protease; Biology; NS2-3 protease; Proteases; Homology modeling; Viral protein; Flaviviridae; Virus; Enzyme; Biochemistry; Viral replication; Hepatitis C virus","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001510231,0.0003231449,0.0002407698,0.0001465344,0.0001636439,0.0003586978,0.0005125431,0.0003270226,0.0005628426],"category_scores_gemma":[0.0002027649,0.0001168565,0.0002898147,0.000293079,0.0001688487,0.0002079251,0.0001084272,0.0004043127,0.0003701584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006249251,"about_ca_system_score_gemma":0.0002929511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00170778,"about_ca_topic_score_gemma":0.0006611742,"domain_scores_codex":[0.9998784,0.00001900136,0.000009428719,0.00002385554,0.00005349865,0.00001577713],"domain_scores_gemma":[0.9999449,0.00001206888,0.00001260074,0.00000639136,0.00001310369,0.00001082844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001511595,0.00006566136,0.0003227945,0.00006586079,0.000007982037,0.0002373854,0.000040731,0.003649266,0.992724,0.0008243076,0.00006744604,0.001843518],"study_design_scores_gemma":[0.00005263314,0.0004015772,0.001733374,0.00001031194,0.0000204815,0.000516404,0.00007345733,0.0406177,0.9486687,0.0003500074,0.007543096,0.00001228241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775656,0.00107573,0.01821942,0.0001342412,0.00001982109,0.00006507408,0.000786533,0.00008294726,0.002050669],"genre_scores_gemma":[0.9749193,0.001171436,0.01892004,0.0000236801,0.000008125964,0.00004690225,0.002856663,0.00002554863,0.00202824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00170778,"threshold_uncertainty_score":0.004534185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01798645675235457,"score_gpt":0.2529408931760239,"score_spread":0.2349544364236694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}