{"id":"W2023590402","doi":"10.1016/j.jalz.2012.03.002","title":"Frontotemporal degeneration, the next therapeutic frontier: Molecules and animal models for frontotemporal degeneration drug development","year":2012,"lang":"en","type":"review","venue":"Alzheimer s & Dementia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Baycrest Hospital; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging","keywords":"Frontotemporal dementia; Drug development; Disease; Drug; Neuroscience; Medicine; Degeneration (medical); Psychology; Dementia; Pathology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000945151,0.0008047189,0.001444069,0.0001711691,0.0006203956,0.0002968559,0.0004110397,0.0004004148,0.0001563616],"category_scores_gemma":[0.00001103845,0.0005229603,0.0004181454,0.0001740039,0.0001699821,0.0005662717,0.0002423443,0.0004604181,0.00005362394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009756428,"about_ca_system_score_gemma":0.0007643603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001585967,"about_ca_topic_score_gemma":0.0001684038,"domain_scores_codex":[0.9959581,0.0003511799,0.001203937,0.0008471254,0.0007637377,0.0008759372],"domain_scores_gemma":[0.9981693,0.00008820441,0.0004603416,0.0006729578,0.0002656947,0.0003435004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001198788,0.0001359362,0.0001007055,0.0006441535,0.01163163,0.000003726652,0.0005613347,0.000007967398,0.00006620954,0.000494431,0.004610191,0.9816238],"study_design_scores_gemma":[0.001047429,0.0001458574,0.0002842348,0.000731039,0.03948653,0.00002877076,0.00004601094,0.002624997,0.0002023143,0.0002196176,0.9544018,0.0007814024],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003112366,0.9879305,0.006692007,0.0004237986,0.0003716735,0.004037482,0.00003634865,0.00007372755,0.0001232387],"genre_scores_gemma":[0.03418708,0.9297306,0.03072503,0.0003828963,0.001109834,0.001863913,0.001605091,0.0002300806,0.0001654983],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9808424,"threshold_uncertainty_score":0.9997222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1877879453906227,"score_gpt":0.3498176878346553,"score_spread":0.1620297424440326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}