{"id":"W2023599988","doi":"10.1242/dev.113506","title":"Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium","year":2015,"lang":"en","type":"article","venue":"Development","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Johns Hopkins University","keywords":"Biology; Histone deacetylase 2; HDAC1; Histone deacetylase; Wnt signaling pathway; Histone; Cancer research; Cell biology; HDAC11; Acetylation; Genetics; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002125677,0.00008687634,0.00007134222,0.00002105169,0.00003930406,0.00001322038,0.00006460679,0.00007181823,0.000001283543],"category_scores_gemma":[0.000008992902,0.00005546746,0.00001074106,0.000045089,0.00005401725,0.000001793561,0.00005877065,0.00005807824,0.000003301342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002458019,"about_ca_system_score_gemma":0.00008767397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001392155,"about_ca_topic_score_gemma":0.00002408694,"domain_scores_codex":[0.9994724,0.00003167292,0.0001132237,0.000171322,0.00008301562,0.000128409],"domain_scores_gemma":[0.9997932,0.000003409014,0.00002915033,0.0000917763,0.00001848351,0.00006394288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008515528,0.000277151,0.007838249,0.0002026847,0.0003454774,0.0002183499,0.02674674,0.0002915668,0.7375411,0.000812495,0.01926923,0.2056054],"study_design_scores_gemma":[0.003671332,0.0005427194,0.09784178,0.0001185889,0.00003393968,0.0004492217,0.001530906,0.00009137416,0.4256183,0.0005387053,0.4687331,0.0008300942],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955571,0.002910639,0.00004809705,0.0003787906,0.00007453628,0.00009355688,0.000001209359,0.000003918818,0.0009321341],"genre_scores_gemma":[0.998176,0.0005330837,0.00050122,0.0003262708,0.00003155108,0.00001911785,0.00001868771,0.000006627291,0.0003874899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4494638,"threshold_uncertainty_score":0.2261897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697483626823914,"score_gpt":0.2326675973714758,"score_spread":0.2156927611032366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}