{"id":"W2023599988","doi":"10.1242/dev.113506","title":"Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium","year":2015,"lang":"en","type":"article","venue":"Development","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Johns Hopkins University","keywords":"Biology; Histone deacetylase 2; HDAC1; Histone deacetylase; Wnt signaling pathway; Histone; Cancer research; Cell biology; HDAC11; Acetylation; Genetics; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008365703,0.0003685706,0.0002245885,0.0003339085,0.0002032232,0.0003660785,0.0001764343,0.0002407489,0.001175582],"category_scores_gemma":[0.00007942844,0.0002311333,0.0002365786,0.0001411881,0.0002502049,0.0002080536,0.000285086,0.0003911779,0.0004071943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004115589,"about_ca_system_score_gemma":0.0003365494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001339734,"about_ca_topic_score_gemma":0.002776429,"domain_scores_codex":[0.9998665,0.00001280396,0.000007578773,0.00003519105,0.00003856641,0.00003923536],"domain_scores_gemma":[0.9999137,0.00000411283,0.00003491408,0.000006165787,0.000009610623,0.00003139614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000899079,0.000006944427,0.0007127123,0.00002068154,0.00000437441,0.00008867581,0.000009645023,0.00003848019,0.9977234,0.0001888254,0.00004059638,0.001075691],"study_design_scores_gemma":[0.00004756437,0.000120408,0.0730373,0.00001226569,0.00003882187,0.0008448443,0.00007162341,0.001688135,0.918923,0.0002162685,0.004990037,0.00000977438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871922,0.005405622,0.0039976,0.0001709183,0.00003358944,0.00002013773,0.0005450862,0.0001460154,0.002489002],"genre_scores_gemma":[0.9905623,0.001460814,0.001315606,0.00005243585,0.000008657498,0.00001736468,0.0004285483,0.0000226447,0.006131717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001339734,"threshold_uncertainty_score":0.003932714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697483626823914,"score_gpt":0.2326675973714758,"score_spread":0.2156927611032366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}