{"id":"W2023603752","doi":"10.1007/s00239-009-9256-z","title":"Aplysia cys-loop Glutamate-Gated Chloride Channels Reveal Convergent Evolution of Ligand Specificity","year":2009,"lang":"en","type":"article","venue":"Journal of Molecular Evolution","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"European Commission; Joint Genome Institute","keywords":"Biology; Bilateria; Rhodopsin-like receptors; Receptor; Annelid; Class C GPCR; Ligand-gated ion channel; Homomeric; Deuterostome; Aplysia; Phylogenetic tree; Glycine receptor; Glutamate receptor; Transmembrane domain; GenBank; Phylogenetics; Genetics; Metabotropic receptor; Ion channel; Evolutionary biology; Amino acid; Gene; Glycine; Protein subunit; Zoology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007082357,0.0002558133,0.0004448501,0.0001822068,0.0000708691,0.00001577949,0.0003180361,0.0002563197,0.00001432831],"category_scores_gemma":[0.0002255458,0.0002427453,0.0003735417,0.0003095352,0.00009806935,0.00001998974,0.00007047456,0.0002672071,0.000009209626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002544002,"about_ca_system_score_gemma":0.0002125584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002252694,"about_ca_topic_score_gemma":0.000002247858,"domain_scores_codex":[0.9977421,0.0001689293,0.0009333396,0.0002977712,0.0005198208,0.0003380625],"domain_scores_gemma":[0.9978084,0.000009595175,0.0009521914,0.0003588823,0.0007036474,0.0001672723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005436608,0.0003203566,0.00121788,0.00002051827,0.0001535463,0.000007934011,0.00004332703,0.001224534,0.9944221,0.0002169058,0.001447735,0.0003815008],"study_design_scores_gemma":[0.001608968,0.001413309,0.005594835,0.00009072855,0.0001317412,0.0002256369,0.0001232779,0.0002219661,0.9888538,0.0003798503,0.001106277,0.0002496037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615436,0.002866328,0.03415014,0.0002019535,0.0007963469,0.0002351904,0.00001003436,0.00001039777,0.0001859606],"genre_scores_gemma":[0.9981477,0.0002725873,0.000692501,0.00005634809,0.0006081836,0.00000150002,0.00002466888,0.00002399843,0.0001725098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03660406,"threshold_uncertainty_score":0.9898868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007106619900567971,"score_gpt":0.2423653526014199,"score_spread":0.2352587327008519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}