{"id":"W2023603752","doi":"10.1007/s00239-009-9256-z","title":"Aplysia cys-loop Glutamate-Gated Chloride Channels Reveal Convergent Evolution of Ligand Specificity","year":2009,"lang":"en","type":"article","venue":"Journal of Molecular Evolution","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"European Commission; Joint Genome Institute","keywords":"Biology; Bilateria; Rhodopsin-like receptors; Receptor; Annelid; Class C GPCR; Ligand-gated ion channel; Homomeric; Deuterostome; Aplysia; Phylogenetic tree; Glycine receptor; Glutamate receptor; Transmembrane domain; GenBank; Phylogenetics; Genetics; Metabotropic receptor; Ion channel; Evolutionary biology; Amino acid; Gene; Glycine; Protein subunit; Zoology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003775499,0.0001698667,0.0002725004,0.0003535179,0.0002916127,0.0006300657,0.0004138677,0.0006457018,0.0005886374],"category_scores_gemma":[0.0005142424,0.0001852037,0.0001996652,0.0002661496,0.0004678087,0.0003665417,0.0005670899,0.001036709,0.0002544692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005734942,"about_ca_system_score_gemma":0.0002763865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007321722,"about_ca_topic_score_gemma":0.001049228,"domain_scores_codex":[0.9998323,0.0000297294,0.0000136075,0.00003486814,0.00005644361,0.00003297342],"domain_scores_gemma":[0.9996868,0.00007878739,0.00006157892,0.00006184469,0.00006473498,0.00004624861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001983676,0.0000213389,0.003252408,0.00002135865,0.00001985479,0.0002420426,0.0001798284,0.0003799809,0.9885337,0.001143766,0.00002733014,0.005980109],"study_design_scores_gemma":[0.0001628588,0.0006117325,0.2520651,0.0000766583,0.0002381355,0.006561953,0.001039254,0.01639038,0.7064285,0.00367392,0.0126404,0.000111091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964184,0.0002215116,0.0017365,0.0001066921,0.000005937094,0.000005927579,0.00004188866,0.00003109539,0.001432006],"genre_scores_gemma":[0.9980928,0.0001824617,0.0009809154,0.0001096976,0.000004324734,0.000003849793,0.00006063699,0.0000132693,0.0005520435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007321722,"threshold_uncertainty_score":0.00416106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007106619900567971,"score_gpt":0.2423653526014199,"score_spread":0.2352587327008519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}