{"id":"W2023603756","doi":"10.1016/j.gene.2012.06.053","title":"Identification of candidate SNPs for drug induced toxicity from differentially expressed genes in associated tissues","year":2012,"lang":"en","type":"review","venue":"Gene","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Cancerfonden; Vetenskapsrådet; Swedish Cancer Foundation; European Commission; Université Laval","keywords":"Biology; Single-nucleotide polymorphism; In silico; Candidate gene; Carboplatin; Gene; Paclitaxel; SNP; Genetics; Computational biology; Bioinformatics; Genotype; Cancer; Cisplatin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004235705,0.0008241892,0.0014644,0.0013445,0.0001205106,0.0006208142,0.0006870512,0.0006942585,0.001503513],"category_scores_gemma":[0.0006565612,0.0001745728,0.0006291527,0.001295552,0.0003148513,0.0004168055,0.0002742533,0.0006497251,0.0004904051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002625661,"about_ca_system_score_gemma":0.000568783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000630977,"about_ca_topic_score_gemma":0.0009033533,"domain_scores_codex":[0.9998075,0.00002302803,0.00003126294,0.00006575444,0.00006117064,0.00001135228],"domain_scores_gemma":[0.9995902,0.0002427933,0.00008357042,0.00001161979,0.00005889089,0.00001292889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002536259,0.00007578694,0.005265388,0.009346135,0.0003813243,0.00116361,0.00003976771,0.0004724656,0.01242639,0.001318742,0.006743344,0.9625133],"study_design_scores_gemma":[0.0002686485,0.0007785463,0.07444937,0.007656679,0.005894265,0.03614981,0.0002910976,0.001934954,0.03368849,0.01177158,0.8269219,0.0001946389],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004128477,0.9910563,0.002428165,0.0006366278,0.000186241,0.00001279104,0.0002190071,0.00004017617,0.00129213],"genre_scores_gemma":[0.01966107,0.9719778,0.004829432,0.0007396021,0.0004087822,0.00002948682,0.0005312256,0.00001216584,0.001810504],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001503513,"threshold_uncertainty_score":0.005029798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04996405822556625,"score_gpt":0.3192991267198321,"score_spread":0.2693350684942658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}