{"id":"W2023630351","doi":"10.1038/ng0904-921","title":"The Knockout Mouse Project","year":2004,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":619,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Research Manitoba","funders":"National Center for Research Resources; National Institute of Mental Health; National Institutes of Health; GlaxoSmithKline; University of Toronto; National Institute on Deafness and Other Communication Disorders; University of Pennsylvania; Wellcome Trust","keywords":"Gene knockout; Biology; Knockout mouse; Computational biology; Function (biology); Gene; Phenotype; Laboratory mouse; Genetics; Gene targeting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003843589,0.001533284,0.001487838,0.002307616,0.001214311,0.001935441,0.003102319,0.00177706,0.04197744],"category_scores_gemma":[0.00215858,0.0007262134,0.001036002,0.001176876,0.0009561103,0.001222142,0.002483093,0.003021258,0.02259653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007968502,"about_ca_system_score_gemma":0.003266594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001624249,"about_ca_topic_score_gemma":0.002326678,"domain_scores_codex":[0.9981062,0.0005069468,0.0001788725,0.0003051907,0.0006740538,0.0002287114],"domain_scores_gemma":[0.9983083,0.0002520047,0.0002044088,0.0003344786,0.0003355505,0.0005652013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001721686,0.0004093058,0.002085168,0.001501907,0.0003859053,0.001125951,0.0001831595,0.001371767,0.1307862,0.03858493,0.5560391,0.2658048],"study_design_scores_gemma":[0.000509865,0.0004739619,0.00254035,0.0003943206,0.0002839941,0.002870212,0.00003123629,0.0008732056,0.02221284,0.007359667,0.9623734,0.00007698773],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.05424495,0.04211627,0.416991,0.01768206,0.009820196,0.005234944,0.1913224,0.04391237,0.2186757],"genre_scores_gemma":[0.08953404,0.05747073,0.2970958,0.01105133,0.001477136,0.01047716,0.3089714,0.007237686,0.2166847],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.04197744,"threshold_uncertainty_score":0.1404285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00672547653062129,"score_gpt":0.2619272453888906,"score_spread":0.2552017688582693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}