{"id":"W2023630351","doi":"10.1038/ng0904-921","title":"The Knockout Mouse Project","year":2004,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":619,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Research Manitoba","funders":"National Center for Research Resources; National Institute of Mental Health; National Institutes of Health; GlaxoSmithKline; University of Toronto; National Institute on Deafness and Other Communication Disorders; University of Pennsylvania; Wellcome Trust","keywords":"Gene knockout; Biology; Knockout mouse; Computational biology; Function (biology); Gene; Phenotype; Laboratory mouse; Genetics; Gene targeting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001359355,0.0001372862,0.00006878659,0.00002017992,0.0002327972,0.00004395318,0.0002488677,0.0003317878,0.000001442379],"category_scores_gemma":[0.00006396393,0.00009290459,0.00007691518,0.000100841,0.00009885741,9.319154e-7,0.0001089992,0.0002520227,0.00001384012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001465454,"about_ca_system_score_gemma":0.0001313879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004944619,"about_ca_topic_score_gemma":0.00004115315,"domain_scores_codex":[0.9990875,0.00002097184,0.0001390429,0.0003465681,0.0001628329,0.0002431289],"domain_scores_gemma":[0.9992714,0.000003300656,0.00005513389,0.000503884,0.0001225348,0.00004378126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001231697,0.00008523677,0.0007090249,0.00001165054,0.00008849665,0.000002746785,0.00007696861,0.001077903,0.9749169,0.0006487622,0.01006255,0.01219658],"study_design_scores_gemma":[0.0002726351,0.0002317276,0.001553778,0.00000234591,0.00001190355,0.00002042609,0.00004713658,0.000005821285,0.5037047,0.0002598322,0.493755,0.0001346663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805277,0.01586615,0.0005015244,0.0006224517,0.0006048941,0.000288795,0.000009028069,0.00002041655,0.001559071],"genre_scores_gemma":[0.9890431,0.003682656,0.001693097,0.000298199,0.001059024,0.0000151945,0.00003639211,0.00003020637,0.004142195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4836925,"threshold_uncertainty_score":0.3788539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00672547653062129,"score_gpt":0.2619272453888906,"score_spread":0.2552017688582693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}