{"id":"W2023684600","doi":"10.1016/s0378-4347(00)00161-4","title":"Metabolic profiling of valproic acid by cDNA-expressed human cytochrome P450 enzymes using negative-ion chemical ionization gas chromatography–mass spectrometry","year":2000,"lang":"en","type":"article","venue":"Journal of Chromatography B Biomedical Sciences and Applications","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Medical Research Council","keywords":"Chemistry; Chromatography; Derivatization; Mass spectrometry; Gas chromatography; Chemical ionization; Reagent; Electron ionization; Selected ion monitoring; Gas chromatography–mass spectrometry; Ion; Ionization; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006096573,0.000226828,0.0006742985,0.0005123446,0.0004227039,0.00004702416,0.0002515847,0.0001361514,0.0001963132],"category_scores_gemma":[0.00005175694,0.0001534606,0.0003362224,0.002667574,0.001855641,0.0002208982,0.00004134788,0.0002748606,9.87262e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002331185,"about_ca_system_score_gemma":0.00009037615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001642645,"about_ca_topic_score_gemma":2.056856e-7,"domain_scores_codex":[0.9976357,0.0000771447,0.0007830917,0.0003404736,0.0008129024,0.0003507466],"domain_scores_gemma":[0.9987236,0.0001385546,0.0004628482,0.0001335744,0.000163575,0.0003778774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003369396,0.0005603316,0.002908773,0.0001091046,0.0001874581,0.00000378275,0.00004693446,0.000002724631,0.9930733,0.0007429001,0.0002136629,0.002117331],"study_design_scores_gemma":[0.002512594,0.001271037,0.01891614,0.0003121864,0.0005809503,0.0001963242,0.0002248669,0.0009324041,0.9691043,0.003609725,0.002026257,0.0003131411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885175,0.004860346,0.005198915,0.0005153025,0.00002574732,0.0005210521,0.00003226604,0.00004232027,0.0002865558],"genre_scores_gemma":[0.9841729,0.001847247,0.01351754,0.000127574,0.0002805801,0.00002886478,0.00001095349,0.00001107027,0.000003305377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02396893,"threshold_uncertainty_score":0.6837186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01798206614880886,"score_gpt":0.3126282169019534,"score_spread":0.2946461507531445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}