{"id":"W2023703161","doi":"10.1016/s0141-0229(01)00444-6","title":"Production and recovery of recombinant protease inhibitor α1-antitrypsin","year":2001,"lang":"en","type":"article","venue":"Enzyme and Microbial Technology","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chromatography; Ammonium sulfate; Flocculation; Chemistry; Recombinant DNA; Yeast extract; Ammonium; Fractionation; Microfiltration; Ammonium chloride; Yeast; Agarose; Protease; Saccharomyces cerevisiae; Fermentation; Biochemistry; Enzyme; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203976,0.0001185856,0.0001665184,0.0001150482,0.00006317744,0.000009067629,0.00006949788,0.0002283808,0.000007132943],"category_scores_gemma":[0.000122978,0.0001056831,0.00003579322,0.000134185,0.0002431876,0.000006926934,0.0001303089,0.00009083151,0.000001767969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006014983,"about_ca_system_score_gemma":0.00002372534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002950686,"about_ca_topic_score_gemma":0.00003862421,"domain_scores_codex":[0.9992682,0.00002490578,0.0001722957,0.0003402345,0.00003374361,0.0001606601],"domain_scores_gemma":[0.9996209,0.000002475215,0.00009476004,0.0001990578,0.00005404058,0.00002883685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000143026,0.00007233482,0.002045365,0.00002066423,0.00003014059,0.000002964071,0.000007847404,3.886006e-7,0.98092,0.00007783978,0.001582095,0.01509729],"study_design_scores_gemma":[0.0002790924,0.0004816082,0.0003763516,0.00003719938,0.00001579438,0.0001655575,0.00003541374,0.000001315723,0.964318,0.0004204299,0.03374035,0.000128844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961272,0.002292679,0.0001273736,0.0008968142,0.000150509,0.0002824313,0.000005497412,0.00001945723,0.0000980749],"genre_scores_gemma":[0.9963623,0.001723097,0.0007454746,0.00004195337,0.0001108579,0.00002249642,0.00001301422,0.00001095811,0.0009698053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03215825,"threshold_uncertainty_score":0.4309632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006136246244635879,"score_gpt":0.2132002336756154,"score_spread":0.2070639874309795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}