{"id":"W2023703161","doi":"10.1016/s0141-0229(01)00444-6","title":"Production and recovery of recombinant protease inhibitor α1-antitrypsin","year":2001,"lang":"en","type":"article","venue":"Enzyme and Microbial Technology","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chromatography; Ammonium sulfate; Flocculation; Chemistry; Recombinant DNA; Yeast extract; Ammonium; Fractionation; Microfiltration; Ammonium chloride; Yeast; Agarose; Protease; Saccharomyces cerevisiae; Fermentation; Biochemistry; Enzyme; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003454871,0.000451853,0.0004978632,0.0003544693,0.0002496642,0.0004391351,0.0003586804,0.0003197717,0.0006188853],"category_scores_gemma":[0.0004114945,0.0002285781,0.0003072605,0.0005874514,0.0001862348,0.0002987535,0.0002145,0.0007121195,0.0006272442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003242948,"about_ca_system_score_gemma":0.0002943829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009536212,"about_ca_topic_score_gemma":0.0007756256,"domain_scores_codex":[0.9997504,0.00002918064,0.00002721152,0.00003888725,0.0001028193,0.00005151896],"domain_scores_gemma":[0.9998572,0.00002704088,0.00003401553,0.00003177028,0.00003094289,0.00001907611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006459725,0.00002341602,0.00008011291,0.00003287194,0.000004699999,0.00005164493,0.00001687405,0.0001491676,0.9974067,0.0001076464,0.0000414295,0.002020879],"study_design_scores_gemma":[0.000006653871,0.00004420148,0.0004340831,0.00000240907,0.000007915319,0.00009261808,0.00000487239,0.0003344418,0.9972774,0.00002266109,0.001770576,0.00000213386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947239,0.004510883,0.04395478,0.0002218324,0.0001050898,0.00011895,0.001267377,0.0003334767,0.002248544],"genre_scores_gemma":[0.9509968,0.00361281,0.029567,0.00004641927,0.00002909859,0.00005946056,0.003857177,0.0001180653,0.01171317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009536212,"threshold_uncertainty_score":0.002352953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006136246244635879,"score_gpt":0.2132002336756154,"score_spread":0.2070639874309795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}