{"id":"W2023718084","doi":"10.1159/000362553","title":"A New Era of Targeting the Ancient Gatekeepers of the Immune System: Toll-Like Agonists in the Treatment of Allergic Rhinitis and Asthma","year":2014,"lang":"en","type":"review","venue":"International Archives of Allergy and Immunology","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Tehran University of Medical Sciences and Health Services; National Institute for Health and Care Research","keywords":"Immunology; Medicine; Allergy; Agonist; Immune system; TLR9; Asthma; Toll-like receptor; Allergic inflammation; Immunotherapy; TLR4; Innate immune system; Receptor; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001275168,0.0002012321,0.0009352688,0.0001185207,0.00004760264,0.000004319386,0.0003591367,0.00008200263,0.00001894603],"category_scores_gemma":[0.00004773027,0.00009042131,0.0003690428,0.00007256459,0.0006236368,0.00001621312,0.0001105149,0.0001712326,3.98134e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001955675,"about_ca_system_score_gemma":0.0002113173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003207001,"about_ca_topic_score_gemma":0.000038182,"domain_scores_codex":[0.9984049,0.0003412928,0.0007621234,0.000182964,0.0001827982,0.0001259453],"domain_scores_gemma":[0.9984471,0.0005041561,0.0006970149,0.0002816333,0.00004530398,0.00002482741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005090534,0.0004696583,0.0001515871,0.00334681,0.002956036,0.00001811853,0.003934922,0.00001971531,0.0003714672,0.004877348,0.00003520905,0.9833101],"study_design_scores_gemma":[0.001934484,0.001483754,0.0186049,0.01137444,0.0002494499,0.0003065149,0.001497203,0.00007843107,0.0001992836,0.0001054156,0.9640166,0.0001494911],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01744225,0.9806151,0.00002284512,0.0002753258,0.0002463676,0.0004231857,0.00004319564,0.000002822078,0.0009288919],"genre_scores_gemma":[0.1030978,0.8965701,0.00006951472,0.00002285337,0.00005299436,0.00002757939,0.00003448418,0.00001145876,0.0001132353],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9831606,"threshold_uncertainty_score":0.3687274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141543139317619,"score_gpt":0.2672460366782286,"score_spread":0.2558306052850524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}