{"id":"W2023718084","doi":"10.1159/000362553","title":"A New Era of Targeting the Ancient Gatekeepers of the Immune System: Toll-Like Agonists in the Treatment of Allergic Rhinitis and Asthma","year":2014,"lang":"en","type":"review","venue":"International Archives of Allergy and Immunology","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Tehran University of Medical Sciences and Health Services; National Institute for Health and Care Research","keywords":"Immunology; Medicine; Allergy; Agonist; Immune system; TLR9; Asthma; Toll-like receptor; Allergic inflammation; Immunotherapy; TLR4; Innate immune system; Receptor; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001085706,0.0005044049,0.0009407529,0.0008893866,0.0002409944,0.001046166,0.0006611033,0.001277365,0.004201593],"category_scores_gemma":[0.0005380256,0.0001704908,0.0006823114,0.0006361763,0.0007045752,0.001794319,0.0007291361,0.00480477,0.001574763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004069482,"about_ca_system_score_gemma":0.0004359195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002868513,"about_ca_topic_score_gemma":0.0008108582,"domain_scores_codex":[0.9996014,0.0001079187,0.0000263866,0.00005917371,0.0001504114,0.00005479766],"domain_scores_gemma":[0.9996439,0.0001162963,0.00005399065,0.00001776095,0.00009496987,0.00007302315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001222687,0.001044781,0.0007005744,0.006348659,0.0002037793,0.0007411971,0.0002664467,0.0005022116,0.06440993,0.01697665,0.0676169,0.8399662],"study_design_scores_gemma":[0.0003921324,0.002375619,0.002364965,0.001141432,0.0001654205,0.002097873,0.000148271,0.0004882967,0.006182759,0.006895386,0.9776909,0.0000570259],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005073952,0.9754722,0.003496694,0.009915712,0.002020153,0.00004288642,0.00009866524,0.0001038396,0.003776015],"genre_scores_gemma":[0.02706619,0.9407406,0.0073582,0.01115498,0.005605096,0.0001088765,0.0002721087,0.00004612475,0.00764782],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004201593,"threshold_uncertainty_score":0.01405573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141543139317619,"score_gpt":0.2672460366782286,"score_spread":0.2558306052850524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}