{"id":"W2023776747","doi":"10.1016/j.semradonc.2010.06.003","title":"DNA Repair Targeting and Radiotherapy: A Focus on the Therapeutic Ratio","year":2010,"lang":"en","type":"review","venue":"Seminars in Radiation Oncology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"DNA damage; DNA repair; DNA; Medicine; Cancer research; Homologous recombination; Radiation therapy; Base excision repair; Biology; Genetics; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001176524,0.0003681542,0.0007334225,0.0001448594,0.0001071347,0.00002465438,0.0002947452,0.001050704,0.00004763883],"category_scores_gemma":[0.0003048962,0.0002695118,0.000260282,0.0001740661,0.0001258044,0.000003819891,0.00007660982,0.000603882,0.00001126596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000168346,"about_ca_system_score_gemma":0.0003979388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005511428,"about_ca_topic_score_gemma":0.00002840011,"domain_scores_codex":[0.9976522,0.0007623779,0.0005227113,0.0006144049,0.0001319014,0.0003164238],"domain_scores_gemma":[0.9985874,0.0003625037,0.0004092717,0.0005475265,0.00003032434,0.00006301288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002521787,0.00006230711,0.000009736346,0.0001987437,0.00009564498,0.00001066959,0.0001133619,0.000002117251,0.002710822,0.001342523,0.002152994,0.9932759],"study_design_scores_gemma":[0.000296098,0.0006261785,0.000003953764,0.0003410302,0.0000873731,0.00006797808,0.00003494061,0.00009107096,0.0008131837,0.0002449717,0.9971177,0.0002755485],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006115242,0.9963076,0.00009832412,0.000353556,0.0005578303,0.001070063,0.00001430521,0.00003613908,0.0009506221],"genre_scores_gemma":[0.0003506569,0.9966987,0.0008420504,0.0005715725,0.0005060687,0.0003814997,0.0001221191,0.00007401028,0.0004532788],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9949647,"threshold_uncertainty_score":0.9999757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01700537503230679,"score_gpt":0.3206632161568777,"score_spread":0.3036578411245709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}