{"id":"W2023782842","doi":"10.1124/dmd.31.4.447","title":"Retention of Transporter Activities in Cryopreserved, Isolated Rat Hepatocytes","year":2003,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Liver physiology and pathology","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Cryopreservation; Trypan blue; Metabolism; Estrone sulfate; Chemistry; Tolbutamide; Dimethyl sulfoxide; Hepatocyte; Andrology; Biochemistry; Estrone; Cell; Biology; Embryo; In vitro; Endocrinology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001472036,0.00008349286,0.000252864,0.00009562352,0.00002962684,0.000002847833,0.00001878836,0.00008292948,0.00008526649],"category_scores_gemma":[0.000009505694,0.00007065306,0.00005187339,0.00008866722,0.00007924793,0.0001626547,0.000004328042,0.00009718302,0.000001935702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004358518,"about_ca_system_score_gemma":0.00001540715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004510336,"about_ca_topic_score_gemma":0.00001343393,"domain_scores_codex":[0.9993756,0.0001371917,0.0001717126,0.0001464967,0.00005796329,0.0001109904],"domain_scores_gemma":[0.9997616,0.00002761946,0.00004937849,0.0001014341,0.00002443638,0.00003548976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002301362,0.0005310203,0.1620193,0.0003517095,0.00007893657,0.00006583922,0.00396427,0.000006756826,0.8146818,0.01430763,0.000153091,0.001538257],"study_design_scores_gemma":[0.002445271,0.00009595112,0.8809206,0.00007777109,0.0001907946,0.00004493269,0.0003640355,0.0001331964,0.1123372,0.002997045,0.0002775387,0.0001156722],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971099,0.001554188,0.0001707797,0.00006858908,0.0001259044,0.0001690361,0.00001176157,0.00001332462,0.00077645],"genre_scores_gemma":[0.9992049,0.0002993241,0.0001305742,0.00008948519,0.00002493861,0.0000131624,0.0000892984,0.000006015423,0.0001422656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7189013,"threshold_uncertainty_score":0.2881148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107378583027549,"score_gpt":0.2329453666333147,"score_spread":0.2222075083305598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}