{"id":"W2023782842","doi":"10.1124/dmd.31.4.447","title":"Retention of Transporter Activities in Cryopreserved, Isolated Rat Hepatocytes","year":2003,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Liver physiology and pathology","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Cryopreservation; Trypan blue; Metabolism; Estrone sulfate; Chemistry; Tolbutamide; Dimethyl sulfoxide; Hepatocyte; Andrology; Biochemistry; Estrone; Cell; Biology; Embryo; In vitro; Endocrinology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003188967,0.0002933524,0.0006460724,0.0002540602,0.0002321001,0.0006386026,0.0003799358,0.0002239686,0.001600926],"category_scores_gemma":[0.0002829352,0.0001428331,0.0004183924,0.000285211,0.0004079801,0.0008553389,0.0001781581,0.0006729978,0.0004239294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000460323,"about_ca_system_score_gemma":0.0004576461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001968408,"about_ca_topic_score_gemma":0.002472624,"domain_scores_codex":[0.9998345,0.00002499307,0.00001796359,0.00004075443,0.00003195607,0.00004973201],"domain_scores_gemma":[0.9997342,0.00006429155,0.0000364005,0.00006660738,0.0000695357,0.0000290714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002820908,0.0000937457,0.002071955,0.00007929326,0.00006778542,0.0001867433,0.0001045071,0.000256967,0.9887764,0.0001767185,0.000118226,0.005246763],"study_design_scores_gemma":[0.00003806825,0.0006262842,0.008726443,0.000007536482,0.00007514948,0.0002010786,0.0001258743,0.001153498,0.9882125,0.00005858477,0.0007629238,0.0000120457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994888,0.002521335,0.001296361,0.0001174362,0.00006835501,0.000009433769,0.0004532612,0.00004730278,0.0005986019],"genre_scores_gemma":[0.995285,0.0006706736,0.0008344237,0.00003839372,0.00002260348,0.00001392713,0.0007062881,0.00002615125,0.002402466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001968408,"threshold_uncertainty_score":0.005355597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107378583027549,"score_gpt":0.2329453666333147,"score_spread":0.2222075083305598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}