{"id":"W2023792956","doi":"10.1042/bj20140606","title":"The crystal structure of the RhoA–AKAP-Lbc DH–PH domain complex","year":2014,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"RHOA; Guanine nucleotide exchange factor; Pleckstrin homology domain; Isothermal titration calorimetry; GTPase; Small GTPase; Nucleotide; Chemistry; Biochemistry; Biophysics; Biology; Phosphorylation; Signal transduction; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002426501,0.0003586128,0.0007147183,0.0002227523,0.0005787878,0.0008508572,0.0009541106,0.0005341679,0.002441946],"category_scores_gemma":[0.0004257651,0.0003049975,0.0001997733,0.0006128104,0.0003152343,0.0003426737,0.0002934998,0.001715354,0.0006207435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001421437,"about_ca_system_score_gemma":0.001087919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005011219,"about_ca_topic_score_gemma":0.004977854,"domain_scores_codex":[0.9998203,0.00001729059,0.000008180533,0.00004060732,0.00008851058,0.00002510911],"domain_scores_gemma":[0.9998615,0.0000326744,0.00002034921,0.00000925854,0.00003276426,0.00004344478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002275571,0.0008713533,0.007013305,0.001891556,0.0003832079,0.002255368,0.0008201574,0.007999578,0.882975,0.006589782,0.0384088,0.04851615],"study_design_scores_gemma":[0.001513133,0.0006911809,0.08961137,0.0002515201,0.0005220015,0.004890773,0.001131115,0.07781433,0.5677738,0.003147174,0.2523886,0.0002650651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9515589,0.01629067,0.005319997,0.00237259,0.0004115533,0.0001471714,0.008311164,0.0006806015,0.01490726],"genre_scores_gemma":[0.941413,0.007078176,0.01035811,0.0006252959,0.00007854997,0.0001511766,0.02863761,0.0001468061,0.01151126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005011219,"threshold_uncertainty_score":0.01031327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007144100773849839,"score_gpt":0.2271810881138426,"score_spread":0.2200369873399927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}