{"id":"W2023792956","doi":"10.1042/bj20140606","title":"The crystal structure of the RhoA–AKAP-Lbc DH–PH domain complex","year":2014,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"RHOA; Guanine nucleotide exchange factor; Pleckstrin homology domain; Isothermal titration calorimetry; GTPase; Small GTPase; Nucleotide; Chemistry; Biochemistry; Biophysics; Biology; Phosphorylation; Signal transduction; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002611755,0.0001246829,0.0001137648,0.00001409975,0.0002899721,0.00004572495,0.0003910217,0.0001363579,0.00004633898],"category_scores_gemma":[0.000169993,0.00006774069,0.0001779421,0.00007361755,0.0002380486,0.000002261742,0.000136912,0.0002090059,0.000001238268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001388654,"about_ca_system_score_gemma":0.00006287089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001616671,"about_ca_topic_score_gemma":0.000002480253,"domain_scores_codex":[0.9989745,0.000140933,0.0002752553,0.0001486955,0.0002448142,0.000215774],"domain_scores_gemma":[0.9992635,0.0000232007,0.0001991043,0.0003075683,0.0001087858,0.00009779125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005181229,0.00001288731,0.000204118,0.00000619144,0.00002734009,3.329393e-7,0.00001289726,0.00002079514,0.9940797,0.0004996408,0.004186308,0.0008979691],"study_design_scores_gemma":[0.0004697729,0.00005360912,0.001393219,0.00002259276,0.00001201762,0.00013921,0.00003359536,0.00008522857,0.908624,0.002720213,0.08633918,0.0001073968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945655,0.0007407984,0.003135292,0.0009471873,0.0001706715,0.0001039617,0.00001653192,0.000004491201,0.0003154994],"genre_scores_gemma":[0.9978499,0.00002523399,0.00108286,0.0002794169,0.0006535375,0.000001192257,0.00001526342,0.00001249292,0.000080046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08545574,"threshold_uncertainty_score":0.2762385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007144100773849839,"score_gpt":0.2271810881138426,"score_spread":0.2200369873399927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}