{"id":"W2023799737","doi":"10.1126/scisignal.2000796","title":"Loops Govern SH2 Domain Specificity by Controlling Access to Binding Pockets","year":2010,"lang":"en","type":"article","venue":"Science Signaling","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"National Institute of General Medical Sciences","keywords":"SH2 domain; Computational biology; Binding site; Plasma protein binding; Binding selectivity; Protein–protein interaction; Biology; Protein domain; Protein structure; Proto-oncogene tyrosine-protein kinase Src; Chemistry; Biophysics; Cell biology; Biochemistry; Phosphorylation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001470805,0.0001991769,0.000171622,0.0001397697,0.0005629192,0.0004062608,0.0007908771,0.0001216295,0.0001164296],"category_scores_gemma":[0.0003316255,0.0001930574,0.00008350158,0.0005947775,0.0002691577,0.00004240747,0.0002809135,0.0002103692,0.00003851449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000369195,"about_ca_system_score_gemma":0.0001925333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002277262,"about_ca_topic_score_gemma":0.00002144139,"domain_scores_codex":[0.997877,0.00003846026,0.0002877728,0.0006987158,0.0005261103,0.000571926],"domain_scores_gemma":[0.9989451,0.0000215841,0.0001308793,0.0003905923,0.0001774987,0.0003343011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003580668,0.00002267418,0.0008831479,0.0000048286,0.000005840737,0.00000282302,0.00004403117,0.0003926097,0.9962365,0.0003333319,0.0002798713,0.001758555],"study_design_scores_gemma":[0.0003672176,0.00005330525,0.0002069906,0.00002469621,0.000005229939,0.000008788373,0.00007590034,0.0003924528,0.9888172,0.0003882984,0.009371795,0.0002881012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9588849,0.0001009496,0.03876737,0.0003401101,0.0004085499,0.0003288912,0.00002918717,0.0000328205,0.001107239],"genre_scores_gemma":[0.9943927,0.000003668669,0.004468785,0.0005380345,0.0003857527,0.00001855246,0.00002325434,0.00002126166,0.0001479894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03550782,"threshold_uncertainty_score":0.7872651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01187841029252538,"score_gpt":0.2765292488240516,"score_spread":0.2646508385315262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}