{"id":"W2023799737","doi":"10.1126/scisignal.2000796","title":"Loops Govern SH2 Domain Specificity by Controlling Access to Binding Pockets","year":2010,"lang":"en","type":"article","venue":"Science Signaling","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"National Institute of General Medical Sciences","keywords":"SH2 domain; Computational biology; Binding site; Plasma protein binding; Binding selectivity; Protein–protein interaction; Biology; Protein domain; Protein structure; Proto-oncogene tyrosine-protein kinase Src; Chemistry; Biophysics; Cell biology; Biochemistry; Phosphorylation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001826259,0.0002657662,0.0001707335,0.0001524017,0.0001597871,0.0004021158,0.0002618124,0.0002370112,0.0009251556],"category_scores_gemma":[0.0002438789,0.0001772689,0.0001436115,0.0001060487,0.0003883328,0.0002947499,0.0002744005,0.000358954,0.0003152694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003058565,"about_ca_system_score_gemma":0.0001716866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004413175,"about_ca_topic_score_gemma":0.0005904884,"domain_scores_codex":[0.9998808,0.0000152238,0.000006582191,0.00002423549,0.00003345066,0.00003962802],"domain_scores_gemma":[0.9998354,0.00005798833,0.00004119866,0.00001642844,0.0000147715,0.00003415499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008517946,0.00001149253,0.000566459,0.00001352072,0.000003822973,0.00003515718,0.00001987705,0.0006474353,0.9966348,0.0003591938,0.00002106995,0.001602141],"study_design_scores_gemma":[0.0000337661,0.0001313893,0.006713785,0.000005815823,0.00001650178,0.0002345517,0.00003340442,0.008226768,0.9819756,0.0005942176,0.002022985,0.00001130427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939324,0.0002245719,0.004701413,0.00002587393,0.000004241135,0.000009094955,0.00003668236,0.00008323112,0.0009823339],"genre_scores_gemma":[0.9990421,0.00005523298,0.0006007744,0.00001264842,0.000002213942,0.000004283837,0.0000331216,0.00001086797,0.0002386682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009251556,"threshold_uncertainty_score":0.003094971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01187841029252538,"score_gpt":0.2765292488240516,"score_spread":0.2646508385315262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}