{"id":"W2023811660","doi":"10.1111/j.1471-4159.2007.04911.x","title":"The effects of oxidative stress on parkin and other E3 ligases","year":2007,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; American Parkinson Disease Association","keywords":"Parkin; Ubiquitin ligase; Ubiquitin; Proteasome; Substantia nigra; Parkinson's disease; Oxidative stress; Biology; Cell biology; Chemistry; Genetics; Dopamine; Biochemistry; Endocrinology; Dopaminergic; Internal medicine; Disease; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002199452,0.0002968693,0.0001813655,0.0001731095,0.0002094609,0.0003461343,0.0001045347,0.0002266711,0.0005679083],"category_scores_gemma":[0.0001407235,0.00008746771,0.0002836537,0.0001364401,0.0001577946,0.0002002432,0.0001636773,0.0002048142,0.00009482127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002139518,"about_ca_system_score_gemma":0.0000782959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005404078,"about_ca_topic_score_gemma":0.000730908,"domain_scores_codex":[0.9998506,0.00003599321,0.0000173399,0.00003488096,0.00002630488,0.00003483887],"domain_scores_gemma":[0.9998951,0.00002734943,0.00002293267,0.00001620935,0.00001800067,0.00002039934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003815502,0.00004236112,0.002393072,0.0000587766,0.0000306069,0.0001114805,0.00002367092,0.00005710073,0.994339,0.00005380317,0.0000183437,0.002490209],"study_design_scores_gemma":[0.00001517195,0.0006627836,0.04549904,0.000005149065,0.00004472763,0.0005686855,0.0000719914,0.0003189559,0.9514546,0.00009870716,0.001255728,0.000004471938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996714,0.002425527,0.0003709793,0.00003460223,0.000007520918,0.000005844329,0.0001106628,0.00000655659,0.0003243866],"genre_scores_gemma":[0.9977908,0.001316018,0.0003347656,0.00002252074,0.000004098325,0.000004147078,0.000118491,0.000002091388,0.0004070725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005679083,"threshold_uncertainty_score":0.001899838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00941866005620672,"score_gpt":0.2714023516419328,"score_spread":0.2619836915857261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}