{"id":"W2023833370","doi":"10.1007/s00709-011-0333-y","title":"Engineering aspects of biological ion channels—from biosensors to computational models for permeation","year":2011,"lang":"en","type":"review","venue":"PROTOPLASMA","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biosensor; Permeation; Biochemical engineering; Biophysics; Ion channel; Nanotechnology; Computational biology; Chemistry; Biology; Engineering; Materials science; Membrane; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001006188,0.001506694,0.001824452,0.001387729,0.0003273155,0.001464306,0.002460437,0.002222155,0.001640571],"category_scores_gemma":[0.00115567,0.0006774179,0.0006290355,0.002773481,0.002007829,0.003032459,0.001124969,0.002462291,0.001650764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001294026,"about_ca_system_score_gemma":0.0009866063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00141033,"about_ca_topic_score_gemma":0.001418786,"domain_scores_codex":[0.9996942,0.0000446187,0.00003291721,0.00006904868,0.000132786,0.00002642398],"domain_scores_gemma":[0.9994599,0.0003083271,0.00004601864,0.00003831498,0.000116104,0.00003138899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007017155,0.0001333092,0.0002030473,0.01060486,0.00010928,0.000210581,0.00008728445,0.007452908,0.01125863,0.04402583,0.02351887,0.9023252],"study_design_scores_gemma":[0.00002787473,0.00007381721,0.000352396,0.001608997,0.0000855232,0.001018771,0.00004967588,0.003397848,0.006208674,0.03836004,0.9487525,0.0000638014],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000436861,0.9865714,0.009936071,0.0006567959,0.0003252288,0.000008190408,0.0000341063,0.00005198181,0.001979279],"genre_scores_gemma":[0.002569021,0.9908954,0.004777108,0.0002712497,0.0002657444,0.00001365463,0.00006379842,0.00001302765,0.001130907],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002460437,"threshold_uncertainty_score":0.009388924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07756175091122057,"score_gpt":0.2956192791854169,"score_spread":0.2180575282741963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}