{"id":"W2023833370","doi":"10.1007/s00709-011-0333-y","title":"Engineering aspects of biological ion channels—from biosensors to computational models for permeation","year":2011,"lang":"en","type":"review","venue":"PROTOPLASMA","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biosensor; Permeation; Biochemical engineering; Biophysics; Ion channel; Nanotechnology; Computational biology; Chemistry; Biology; Engineering; Materials science; Membrane; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138294,0.000228457,0.0004298313,0.0001252996,0.00003522439,0.00001136295,0.0001132024,0.0003615962,0.00002036069],"category_scores_gemma":[0.00008253875,0.0001952683,0.0002399899,0.0001001053,0.00001756244,0.000004083235,0.00005074722,0.00006128519,0.00001453566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002397124,"about_ca_system_score_gemma":0.00006677389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003170922,"about_ca_topic_score_gemma":6.344046e-7,"domain_scores_codex":[0.9989917,0.00003690213,0.0003495358,0.0003876875,0.00008364915,0.0001505411],"domain_scores_gemma":[0.9994262,0.00003178275,0.0001762012,0.0001550883,0.0001450728,0.00006565516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007053689,0.0004955955,0.00001278635,0.01098601,0.0008994579,0.000002279181,0.0004507343,0.1228665,0.005795065,0.02254703,0.001982197,0.833257],"study_design_scores_gemma":[0.0003423025,0.0004364151,0.000004067115,0.000846485,0.00008096778,0.00001072906,0.00000744621,0.02164794,0.004105091,0.001024499,0.9710991,0.0003948997],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002656037,0.5567048,0.4226341,0.00004441266,0.00289573,0.01356173,0.0007169751,0.00009918137,0.0006870851],"genre_scores_gemma":[0.01946701,0.9340764,0.02184933,0.0000834482,0.00426223,0.006837987,0.01253509,0.0002029776,0.000685544],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.969117,"threshold_uncertainty_score":0.7962811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07756175091122057,"score_gpt":0.2956192791854169,"score_spread":0.2180575282741963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}