{"id":"W2023863144","doi":"10.1016/j.stem.2009.01.005","title":"Exploring Pluripotency with Chemical Genetics","year":2009,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; McMaster University","funders":"Canadian Institutes of Health Research","keywords":"GSK-3; Biology; Glycogen synthase; Regulator; Kinase; Bisindolylmaleimide; GSK3B; Chemical biology; Small molecule; Biochemistry; Cell biology; Enzyme; Protein kinase A; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001606984,0.000280743,0.0002032464,0.00006141216,0.00008990082,0.00004756833,0.0004448986,0.0001466575,0.00002924424],"category_scores_gemma":[0.00000297628,0.0002484679,0.00009970107,0.0001695765,0.00006920769,0.000008848584,0.0001281053,0.0002034509,0.0001345162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003629784,"about_ca_system_score_gemma":0.0001015698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003962283,"about_ca_topic_score_gemma":0.000001552763,"domain_scores_codex":[0.9980137,0.00005481127,0.0002500653,0.0006265927,0.0003707175,0.0006841608],"domain_scores_gemma":[0.9988675,0.00001157329,0.00007844435,0.0006549489,0.0001036485,0.0002838771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001023493,0.0001738512,0.0002846438,0.00005148942,0.00001069311,0.00003771317,0.00005831491,0.0001883071,0.992643,0.000005534029,0.0008976483,0.005546466],"study_design_scores_gemma":[0.0007870169,0.0005769755,0.0003534816,0.00001540539,0.000016713,0.00001947615,0.00009096763,0.0001203467,0.9683411,0.00000963635,0.02932254,0.0003463669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.960439,0.00208624,0.000975398,0.0000954823,0.00009231451,0.0002991286,0.00000654011,0.00003784888,0.03596804],"genre_scores_gemma":[0.9909276,0.001044896,0.001426493,0.0001431741,0.0002564988,0.00002847393,0.00005371049,0.00004577582,0.006073398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03048857,"threshold_uncertainty_score":0.9999968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03423836789818967,"score_gpt":0.2344715965935085,"score_spread":0.2002332286953188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}