{"id":"W2023863144","doi":"10.1016/j.stem.2009.01.005","title":"Exploring Pluripotency with Chemical Genetics","year":2009,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; McMaster University","funders":"Canadian Institutes of Health Research","keywords":"GSK-3; Biology; Glycogen synthase; Regulator; Kinase; Bisindolylmaleimide; GSK3B; Chemical biology; Small molecule; Biochemistry; Cell biology; Enzyme; Protein kinase A; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000556795,0.0004249913,0.0002210521,0.0004672425,0.0004087114,0.0006716854,0.0004757833,0.0005067383,0.002205071],"category_scores_gemma":[0.0003954576,0.00027169,0.0003319413,0.0002895622,0.001264942,0.0008994468,0.0006779187,0.001303801,0.0004613707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006447309,"about_ca_system_score_gemma":0.0005424466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005334396,"about_ca_topic_score_gemma":0.0007920382,"domain_scores_codex":[0.999787,0.0000507142,0.00001318566,0.00003801203,0.0000870186,0.00002403283],"domain_scores_gemma":[0.9998092,0.00008629305,0.00002726473,0.00003621821,0.00002135964,0.00001964858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007682697,0.0000422435,0.0003354576,0.0001211124,0.00001323038,0.0001364786,0.0000626051,0.0005547576,0.9446746,0.03905592,0.0003579077,0.01456896],"study_design_scores_gemma":[0.00004692865,0.0001790934,0.0004503361,0.00001771463,0.00002366509,0.0003090758,0.00005168329,0.001363003,0.9603824,0.01216006,0.02499852,0.00001755607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5285125,0.01328511,0.3503325,0.008865546,0.00087604,0.0005055452,0.001065954,0.001019024,0.09553763],"genre_scores_gemma":[0.8745322,0.01241424,0.09483089,0.001334648,0.0001586552,0.0002731791,0.0005338099,0.0002106713,0.01571164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002205071,"threshold_uncertainty_score":0.00737673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03423836789818967,"score_gpt":0.2344715965935085,"score_spread":0.2002332286953188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}