{"id":"W2023866076","doi":"10.4161/19336896.2014.983398","title":"Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding","year":2014,"lang":"en","type":"article","venue":"Prion","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"SOD1; Amyotrophic lateral sclerosis; Cell biology; Biology; Extracellular; Superoxide dismutase; Intracellular; Mutant; Mutation; Biogenesis; Amyloid (mycology); Biochemistry; Disease; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006911284,0.0005323726,0.0003566264,0.0004636713,0.0003226023,0.0009223915,0.000394696,0.0009138632,0.001383626],"category_scores_gemma":[0.0006912868,0.0002624887,0.0006229209,0.0001425002,0.0004927825,0.001681095,0.0009146852,0.0006846981,0.0007995333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002494275,"about_ca_system_score_gemma":0.0001754718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008313249,"about_ca_topic_score_gemma":0.000099795,"domain_scores_codex":[0.9995203,0.0001136014,0.00009834451,0.00008887948,0.0001066485,0.00007230814],"domain_scores_gemma":[0.9992712,0.0001513137,0.0002140695,0.0001551126,0.0001170511,0.00009124813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000607606,0.0001802589,0.00430989,0.0001978585,0.0000430313,0.001349958,0.0001103746,0.0000890286,0.986559,0.002087294,0.0001423746,0.004323241],"study_design_scores_gemma":[0.0001767058,0.0007821141,0.08413251,0.00007554625,0.0001316058,0.00667979,0.0002663739,0.004633424,0.8959603,0.002066193,0.005053126,0.00004249469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869658,0.003769224,0.00699726,0.0001666861,0.00007716352,0.00007525062,0.0001382709,0.00007522701,0.001735041],"genre_scores_gemma":[0.9945241,0.001188591,0.002381214,0.000058483,0.00002502937,0.00004979289,0.0002126681,0.00001389554,0.001546272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001383626,"threshold_uncertainty_score":0.004628718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02174006762896461,"score_gpt":0.2647176228166324,"score_spread":0.2429775551876678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}