{"id":"W2023872605","doi":"10.1042/bj20140761","title":"Molecular effects of cancer-associated somatic mutations on the structural and target recognition properties of Keap1","year":2015,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"KEAP1; Isothermal titration calorimetry; Repressor; Transcription factor; Somatic cell; Biology; Mutation; Oxidative stress; Genetics; Chemistry; Cell biology; Biochemistry; Gene; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304569,0.0002688189,0.0001629978,0.0001386593,0.00009498824,0.0000930812,0.0001545688,0.0002611477,0.001202358],"category_scores_gemma":[0.0002398732,0.0000814821,0.0001964226,0.0001523684,0.0002107864,0.0001181614,0.00009886524,0.0002899559,0.0001344841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001380586,"about_ca_system_score_gemma":0.00008723373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006404656,"about_ca_topic_score_gemma":0.0004295775,"domain_scores_codex":[0.9998875,0.00003054776,0.00001201074,0.0000244839,0.00002638791,0.00001911342],"domain_scores_gemma":[0.9998664,0.00004518999,0.00004056739,0.00001365352,0.00001191759,0.00002229612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003193113,0.00005649855,0.0006011361,0.00003386243,0.00001865662,0.0001936961,0.00001564658,0.0002550231,0.9968618,0.00007186215,0.00005000155,0.00152245],"study_design_scores_gemma":[0.00002971568,0.0008968118,0.02111543,0.000007263282,0.00007025815,0.001089904,0.0000455908,0.002459937,0.9729183,0.0001256401,0.001226945,0.00001408944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987729,0.0004091654,0.0002775716,0.00004284682,0.00001053279,0.000005522629,0.000188619,0.000019216,0.0002736897],"genre_scores_gemma":[0.9991422,0.0002121108,0.0002454498,0.00003609594,0.000003152723,0.000004492035,0.0001342868,0.000008450992,0.0002138018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001202358,"threshold_uncertainty_score":0.004022241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907143117677455,"score_gpt":0.2462858272116407,"score_spread":0.2272143960348662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}