{"id":"W2023887529","doi":"10.1053/gast.2000.16510","title":"NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2","year":2000,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":706,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Medical Research Council; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Medical Research Council Canada; Canadian Association of Gastroenterology; AstraZeneca","keywords":"Celecoxib; Cyclooxygenase; COX-2 inhibitor; Pharmacology; Ketorolac; Prostaglandin; Prostaglandin E2; Medicine; Chemistry; Internal medicine; Enzyme; Analgesic; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003367449,0.0009869913,0.0009084732,0.0008716294,0.0003968114,0.0004607932,0.0004722121,0.0007385711,0.002089143],"category_scores_gemma":[0.0004944053,0.0006965847,0.0005768451,0.0002976405,0.0009088239,0.0009116617,0.0003275565,0.001385039,0.0003586402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005865683,"about_ca_system_score_gemma":0.0008095638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001762502,"about_ca_topic_score_gemma":0.003935616,"domain_scores_codex":[0.9996989,0.00004090324,0.00002401712,0.00004151952,0.00005934457,0.0001352971],"domain_scores_gemma":[0.9988581,0.0001145703,0.000336844,0.0001424627,0.0001049727,0.000443043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01279705,0.0004422604,0.001029151,0.00008174452,0.00003531488,0.000237537,0.00003355943,0.0001100189,0.9823865,0.0001937614,0.00007291103,0.002580137],"study_design_scores_gemma":[0.0002915248,0.005077192,0.01698755,0.00001596504,0.00009995806,0.0003952215,0.0001326736,0.000953305,0.9750901,0.0001519692,0.0007834048,0.00002108945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960937,0.001840024,0.0008641233,0.0001818829,0.0000541231,0.00003509091,0.0001883979,0.00006235343,0.0006802589],"genre_scores_gemma":[0.994117,0.001327275,0.001608321,0.00007950052,0.0000347744,0.00007444227,0.0003993969,0.00002217912,0.002337062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002089143,"threshold_uncertainty_score":0.006988883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01320274528975421,"score_gpt":0.2578158831775142,"score_spread":0.24461313788776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}