{"id":"W2023894807","doi":"10.1016/j.humimm.2005.03.009","title":"Regulation of TNF-Related Apoptosis-Inducing Ligand-Mediated Death-Signal Pathway in Human β Cells by Fas-Associated Death Domain and Nuclear Factor κB","year":2005,"lang":"en","type":"article","venue":"Human Immunology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Medical School, University of Michigan; Canadian Diabetes Association; University of Michigan","keywords":"FADD; Apoptosis; Transfection; Death domain; Cytotoxicity; Molecular biology; Caspase 8; Programmed cell death; Tumor necrosis factor alpha; Chemistry; Biology; Cell culture; Cell biology; Caspase; Immunology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002219609,0.0002374408,0.0003230747,0.0001528141,0.0001931572,0.00002046482,0.0001492556,0.0006196799,0.0001267383],"category_scores_gemma":[0.00001489802,0.000244704,0.00008197217,0.0001069004,0.0001025207,0.00001413576,0.0001064198,0.0002032732,0.000006626177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000716689,"about_ca_system_score_gemma":0.00002626285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001175713,"about_ca_topic_score_gemma":0.00007384416,"domain_scores_codex":[0.9984109,0.0001640086,0.0005354574,0.000425612,0.0001192703,0.0003447149],"domain_scores_gemma":[0.9992952,0.00001839153,0.0003012365,0.0002646459,0.00006852119,0.000052042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004005235,0.0001587437,0.0005486887,0.000009250568,0.00008967095,8.500981e-7,0.0005053501,0.00002897256,0.9959734,0.001332264,0.00006152853,0.001251219],"study_design_scores_gemma":[0.00217618,0.0005291121,0.02581174,0.00004524559,0.000017616,0.000005622552,0.0001385938,0.0001247593,0.9681777,0.000539035,0.002132006,0.0003023493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984065,0.0007109207,0.00006857247,0.00004077315,0.00007183569,0.0002615321,0.00003242334,0.00003019394,0.0003772634],"genre_scores_gemma":[0.9984511,0.0001177108,0.0001485047,0.00003503539,0.0000441391,0.000008993254,0.0006723327,0.00004360577,0.0004785859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02779567,"threshold_uncertainty_score":0.9978739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00799280390160298,"score_gpt":0.2150836147369377,"score_spread":0.2070908108353347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}