{"id":"W2023901707","doi":"10.1002/jlcr.25804401122","title":"Synthesis of 2, 16α‐ and 4, 16α‐[16α‐<sup>18</sup>F]difluoroestradiols and their 11β‐methoxy derivatives for estrogen receptor imaging","year":2001,"lang":"en","type":"article","venue":"Journal of Labelled Compounds and Radiopharmaceuticals","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Estrone; Stereoselectivity; Nucleophilic substitution; Ether; Electrophile; Hydrolysis; Medicinal chemistry; Nucleophile; Reagent; Sulfate; Estrone sulfate; Electrophilic substitution; Salt (chemistry); Stereochemistry; Organic chemistry; Hormone; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008287402,0.0003184176,0.0006654794,0.0001268981,0.000188966,0.00007421739,0.0001783442,0.000187733,0.00001705254],"category_scores_gemma":[0.0002121701,0.0002295057,0.0001945566,0.0001172985,0.0004053277,0.00003554083,0.00009133133,0.0002697124,2.76577e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001619823,"about_ca_system_score_gemma":0.00007148077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002456719,"about_ca_topic_score_gemma":7.610472e-8,"domain_scores_codex":[0.9983048,0.0002430075,0.0006256493,0.000314519,0.0001471455,0.0003648906],"domain_scores_gemma":[0.9984692,0.0004942068,0.000352685,0.0001646616,0.0001748149,0.0003444525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001103921,0.0003195433,0.005136904,0.000133744,0.000838406,0.00002328279,0.0002515296,0.00002277313,0.9557818,0.000162768,0.0008342097,0.03539109],"study_design_scores_gemma":[0.01028655,0.001441762,0.0005642067,0.0003465606,0.0006362572,0.003106571,0.0008372003,0.003777365,0.927932,0.0006797559,0.04975466,0.0006370707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9518456,0.04589485,0.0008388161,0.0007621606,0.0000906489,0.0003240699,0.00003146079,0.000007527472,0.0002048422],"genre_scores_gemma":[0.9706635,0.02317651,0.005522011,0.0001535171,0.0002928404,0.00001371059,0.000006526702,0.00003950438,0.0001319221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04892045,"threshold_uncertainty_score":0.9358971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01805971048912642,"score_gpt":0.2973438253191995,"score_spread":0.279284114830073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}