{"id":"W2023906705","doi":"10.1038/nm.1908","title":"A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer","year":2009,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Gene expression and cancer classification","field":"Biochemistry, Genetics and Molecular Biology","cited_by":616,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Erasmus+; Université de Lausanne; Erasmus Medisch Centrum","keywords":"Epirubicin; Breast cancer; Chemotherapy; Oncology; Gene signature; Cyclophosphamide; Stromal cell; Internal medicine; Estrogen receptor; Medicine; Stroma; Fluorouracil; Cancer; Cancer research; Biology; Gene; Gene expression; Immunohistochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002112358,0.0001181992,0.0001647697,0.0005920166,0.0001556616,0.0003154651,0.0001130356,0.0002248983,0.001069022],"category_scores_gemma":[0.0006445819,0.00007068893,0.0001153829,0.000470183,0.0002301593,0.0001162237,0.0001383798,0.0001991309,0.0001836241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001644016,"about_ca_system_score_gemma":0.000151717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003851758,"about_ca_topic_score_gemma":0.0007089286,"domain_scores_codex":[0.9999037,0.00002579766,0.00001186859,0.00001655493,0.00002152127,0.00002049802],"domain_scores_gemma":[0.9995636,0.0001324997,0.0001622048,0.00001965912,0.00004769931,0.00007433454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001319512,0.00006676596,0.9115232,0.00003349081,0.00004773751,0.0002390755,0.00005858305,0.0003095515,0.07477884,0.00008856294,0.000244397,0.01129037],"study_design_scores_gemma":[0.00002078151,0.0002725193,0.9896351,0.000005887607,0.00005560902,0.001174501,0.0001051564,0.001601908,0.006385476,0.0001531634,0.0005856175,0.000004299782],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990916,0.0001915825,0.0001020555,0.00005415228,0.000005276133,0.000003351809,0.00009847,0.000003139815,0.0004503675],"genre_scores_gemma":[0.9993099,0.00009747356,0.0001590275,0.00002601659,0.0000107453,0.000004786158,0.0001912773,0.000001890688,0.0001987939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001069022,"threshold_uncertainty_score":0.003576219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003775294202432117,"score_gpt":0.2668846344777426,"score_spread":0.2631093402753105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}