{"id":"W2023965168","doi":"10.1038/cdd.2013.93","title":"BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1","year":2013,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Mitosis; Cell biology; Aurora B kinase; Biology; Aurora inhibitor; Ubiquitin ligase; Mitotic exit; Aurora A kinase; Programmed cell death; Ubiquitin; Kinase; PLK1; Aurora kinase; Apoptosis; Phosphorylation; Cancer research; Cell cycle; Cell; Spindle apparatus; Cell division; Biochemistry; Anaphase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003784549,0.0001471173,0.0001068633,0.0000276085,0.0001535184,0.00005659331,0.00003592889,0.0001789978,0.00006264803],"category_scores_gemma":[0.000008519008,0.000131278,0.00004088296,0.00003459753,0.00001740292,0.00001171128,0.00003691392,0.00002763749,0.000004316232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001226962,"about_ca_system_score_gemma":0.000007016138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005762527,"about_ca_topic_score_gemma":0.000004552799,"domain_scores_codex":[0.9992718,0.00001850477,0.0001530419,0.0003185517,0.00007306133,0.0001650735],"domain_scores_gemma":[0.9996251,0.000009552038,0.00008960551,0.0001150825,0.00006600734,0.00009458342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003399375,0.00004069051,0.0022221,0.00002970408,0.00001795197,2.381372e-8,0.00003562756,5.257082e-7,0.9700317,0.00001607439,0.02304103,0.004530591],"study_design_scores_gemma":[0.001028399,0.0001814592,0.01043926,0.000005195655,0.00005088987,0.000001019835,0.00002143122,0.005101689,0.9706581,0.0002484739,0.0120666,0.0001975131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816613,0.003642557,0.01388271,0.0001302281,0.00008109364,0.0004554728,0.00007355547,0.00001170215,0.00006141292],"genre_scores_gemma":[0.9886766,0.001194188,0.0004112,0.0001507571,0.00003532824,0.00007106849,0.003369131,0.00001958611,0.006072116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01347151,"threshold_uncertainty_score":0.5353361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004694067148449377,"score_gpt":0.1878137482545589,"score_spread":0.1831196811061095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}