{"id":"W2023965168","doi":"10.1038/cdd.2013.93","title":"BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1","year":2013,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Mitosis; Cell biology; Aurora B kinase; Biology; Aurora inhibitor; Ubiquitin ligase; Mitotic exit; Aurora A kinase; Programmed cell death; Ubiquitin; Kinase; PLK1; Aurora kinase; Apoptosis; Phosphorylation; Cancer research; Cell cycle; Cell; Spindle apparatus; Cell division; Biochemistry; Anaphase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002940718,0.0004148627,0.0003962653,0.0007747336,0.0007099684,0.0009330662,0.0004949428,0.0003828114,0.00343263],"category_scores_gemma":[0.0002303474,0.0003692867,0.0003812525,0.000344552,0.000329191,0.0005003631,0.0005604386,0.0008820716,0.001406488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001104914,"about_ca_system_score_gemma":0.0003937405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006145205,"about_ca_topic_score_gemma":0.0007645353,"domain_scores_codex":[0.999706,0.00002226896,0.00001892171,0.00007077971,0.0000754193,0.0001065481],"domain_scores_gemma":[0.999754,0.00001722145,0.00009694457,0.00002106882,0.00002051723,0.00009033798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004956523,0.00004795092,0.0005220578,0.00005616503,0.00001707124,0.0003002494,0.00001570578,0.00005613563,0.9949592,0.0005346789,0.0002472968,0.002747688],"study_design_scores_gemma":[0.0000391124,0.0001048795,0.009789217,0.000008565306,0.00001470585,0.001082688,0.00003708997,0.0005966005,0.9811276,0.0001607796,0.007027205,0.00001156719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870346,0.003706749,0.003856852,0.0003617643,0.0001618427,0.00002776557,0.0009284772,0.0003839922,0.003537897],"genre_scores_gemma":[0.9857184,0.001091579,0.002239689,0.0001619118,0.00004626715,0.00004169238,0.00257069,0.00008736361,0.008042271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00343263,"threshold_uncertainty_score":0.01148331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004694067148449377,"score_gpt":0.1878137482545589,"score_spread":0.1831196811061095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}