{"id":"W2023967315","doi":"10.1016/j.cbi.2010.06.006","title":"Hepatocyte or serum albumin protein carbonylation by oxidized fructose metabolites: Glyceraldehyde or glycolaldehyde as endogenous toxins?","year":2010,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Protein Carbonylation; Chemistry; Glycolaldehyde; Glyceraldehyde; Glyoxal; Bovine serum albumin; Biochemistry; Fructose; Serum albumin; Oxidative stress; Lipid peroxidation; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000808347,0.0003680145,0.0003806719,0.0002870754,0.0002341119,0.0007456449,0.0003572472,0.001064807,0.003020406],"category_scores_gemma":[0.000569287,0.0001361892,0.0002455302,0.0002096449,0.001150255,0.001699839,0.0003333052,0.0005832279,0.0004297212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004814521,"about_ca_system_score_gemma":0.0003415009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005716332,"about_ca_topic_score_gemma":0.0008646914,"domain_scores_codex":[0.9998108,0.00005893198,0.000008407329,0.00002825414,0.00003019588,0.00006351523],"domain_scores_gemma":[0.9997141,0.00005748138,0.0000904378,0.00002796846,0.00004888296,0.00006109042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006215164,0.0008871905,0.05289975,0.001694707,0.0005157003,0.006537027,0.001345909,0.0007719749,0.6505541,0.1330159,0.01262691,0.1329356],"study_design_scores_gemma":[0.00042901,0.005097599,0.1625817,0.0004381166,0.0007590042,0.0155564,0.004300347,0.006672931,0.5757899,0.08762894,0.1405282,0.0002178064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8226259,0.1085358,0.02207837,0.02780675,0.00196564,0.0000540369,0.0002513464,0.0001884552,0.01649375],"genre_scores_gemma":[0.9723004,0.01881803,0.001632439,0.001431263,0.0007130457,0.00002406552,0.0001019522,0.00001442034,0.004964361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003020406,"threshold_uncertainty_score":0.01010424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05399854732134608,"score_gpt":0.3203705238945465,"score_spread":0.2663719765732004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}