{"id":"W2023967315","doi":"10.1016/j.cbi.2010.06.006","title":"Hepatocyte or serum albumin protein carbonylation by oxidized fructose metabolites: Glyceraldehyde or glycolaldehyde as endogenous toxins?","year":2010,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Protein Carbonylation; Chemistry; Glycolaldehyde; Glyceraldehyde; Glyoxal; Bovine serum albumin; Biochemistry; Fructose; Serum albumin; Oxidative stress; Lipid peroxidation; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002259776,0.0005700996,0.0008937854,0.0001657045,0.0002645653,0.0001143158,0.0003308172,0.0004512082,0.00877576],"category_scores_gemma":[0.002551005,0.0003655333,0.0004287467,0.0004799664,0.0002810297,0.0003628019,0.000143542,0.001114701,0.0004541547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001238757,"about_ca_system_score_gemma":0.0003274213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002950063,"about_ca_topic_score_gemma":0.00010475,"domain_scores_codex":[0.997086,0.0001178829,0.0008096804,0.0008790337,0.0003443026,0.0007631344],"domain_scores_gemma":[0.9974875,0.000332077,0.000306546,0.0007747618,0.0002776588,0.0008214516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00495294,0.001228645,0.0006120964,0.00005576768,0.0001784497,0.0001864593,0.0001977882,3.233551e-7,0.9879568,0.0003283612,0.002426254,0.001876111],"study_design_scores_gemma":[0.00359443,0.0004488828,0.0007298326,0.00007530863,0.0003227523,0.0007428679,0.0003750048,0.0001089401,0.7850465,0.0003957441,0.2076378,0.0005219499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840435,0.0005219579,0.0000387157,0.000749914,0.0008585107,0.001711154,0.0003146251,0.0004776281,0.01128393],"genre_scores_gemma":[0.983022,0.0001946376,0.001619206,0.001964059,0.0008896599,0.0007182402,0.000550375,0.00006418161,0.0109776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2052115,"threshold_uncertainty_score":0.9998797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05399854732134608,"score_gpt":0.3203705238945465,"score_spread":0.2663719765732004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}