{"id":"W2023984097","doi":"10.1016/j.ccr.2007.10.003","title":"Bmi1 and Cell of Origin Determinants of Brain Tumor Phenotype","year":2007,"lang":"en","type":"letter","venue":"Cancer Cell","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"BMI1; Biology; Neural stem cell; Phenotype; Cancer research; Cancer stem cell; Precursor cell; Stem cell; Cell; Lineage (genetic); Brain tumor; Regulator; Pathology; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001985493,0.0003480848,0.001072979,0.0001522729,0.00002148019,0.000006320377,0.0001538203,0.0003432041,0.001127789],"category_scores_gemma":[0.00001364165,0.000308186,0.0002032596,0.0001760708,0.0001958593,0.00003694764,0.00006178017,0.0006128432,0.000009147893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001560558,"about_ca_system_score_gemma":0.0005093379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002358629,"about_ca_topic_score_gemma":0.0002348728,"domain_scores_codex":[0.9981014,0.00003354927,0.0005837283,0.0004596125,0.0004015273,0.0004201573],"domain_scores_gemma":[0.9985232,0.0001254933,0.000543339,0.0005114542,0.0001705919,0.0001259238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002310275,0.00008833977,0.003641295,0.009391035,0.00006198198,0.0003862001,0.0002499241,8.69941e-7,0.0207368,8.939233e-7,0.9528837,0.01232789],"study_design_scores_gemma":[0.001475777,0.0002520559,0.0004293464,0.0004950151,0.0004734452,0.0000145486,0.00003848681,0.000005425908,0.1577161,0.000007239888,0.8388388,0.0002537342],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.7070386,0.1392576,0.0001502156,0.05840674,0.005046762,0.003233999,0.002295469,0.0001048526,0.08446576],"genre_scores_gemma":[0.1238231,0.01344167,0.003457692,0.754601,0.009760419,0.0001237876,0.0003059723,0.0005281101,0.09395829],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6961942,"threshold_uncertainty_score":0.999937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02679227667900691,"score_gpt":0.3044451791462515,"score_spread":0.2776529024672446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}