{"id":"W2024031924","doi":"10.1038/cdd.2011.117","title":"PI3K/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis","year":2011,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Regione Liguria; Associazione Italiana per la Ricerca sul Cancro; McGill University","keywords":"Myogenesis; Myogenin; PI3K/AKT/mTOR pathway; C2C12; Protein kinase B; Cell biology; microRNA; Biology; Skeletal muscle; Myocyte; Signal transduction; Genetics; Gene; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421313,0.0002706884,0.0002125957,0.000176963,0.0001646588,0.0004870698,0.0001459744,0.0002084255,0.001231375],"category_scores_gemma":[0.00009251963,0.0002293934,0.0001921744,0.0001192365,0.0002599182,0.0003156598,0.0002615544,0.0004016198,0.0005840284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002878713,"about_ca_system_score_gemma":0.0002244059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001726206,"about_ca_topic_score_gemma":0.0002888465,"domain_scores_codex":[0.9998479,0.00001343813,0.000011047,0.0000479493,0.00003297399,0.00004657059],"domain_scores_gemma":[0.9999369,0.000005996068,0.00001992103,0.000006058041,0.000006822778,0.0000243616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001056236,0.000006086198,0.0003134114,0.00001416278,0.00000212534,0.00004593921,0.00001012544,0.00003166079,0.9982108,0.000296034,0.00002065909,0.0009433848],"study_design_scores_gemma":[0.00002275789,0.000143078,0.01540731,0.000006939943,0.00001946266,0.0004990254,0.00004036162,0.0009797829,0.9799597,0.0003503147,0.002562713,0.000008383617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938594,0.001267464,0.002853648,0.00006237082,0.00001662173,0.000009037774,0.0001505004,0.0001050625,0.001676084],"genre_scores_gemma":[0.9960951,0.0005907289,0.001554149,0.00002345129,0.000007084132,0.00001005146,0.0001513609,0.00001599735,0.001551941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001231375,"threshold_uncertainty_score":0.004119337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02131275919544966,"score_gpt":0.2433216752595922,"score_spread":0.2220089160641426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}