{"id":"W2024032952","doi":"10.1016/s0093-7754(03)00228-8","title":"Critical issues in the clinical testing of cancer vaccines: summary of a panel discussion at a symposium entitled ?cancer vaccines: are they here yet?? conducted in Toronto, Canada, December 2002","year":2003,"lang":"en","type":"article","venue":"Seminars in Oncology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Medicine; Clinical trial; Clinical endpoint; Population; Surrogate endpoint; Cancer; Intensive care medicine; Randomized controlled trial; Vaccine efficacy; Adjuvant; Cancer vaccine; Clinical study design; Vaccination; Oncology; Immunology; Internal medicine; Immunotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08103539,0.00180793,0.002362206,0.001653339,0.005976952,0.008992781,0.004714443,0.03845709,0.004184244],"category_scores_gemma":[0.08634273,0.001395238,0.00283087,0.00231992,0.004516432,0.007914327,0.004306479,0.03111022,0.001374589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009304512,"about_ca_system_score_gemma":0.02695842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01089037,"about_ca_topic_score_gemma":0.03922284,"domain_scores_codex":[0.9703268,0.01442969,0.003601615,0.00177014,0.007402886,0.002468882],"domain_scores_gemma":[0.9120683,0.04777705,0.006282707,0.001089339,0.02279153,0.009991006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002535345,0.0001159822,0.0008723632,0.002363428,0.0001242751,0.0006678904,0.002055913,0.0003289446,0.001147492,0.004166456,0.9216357,0.06626794],"study_design_scores_gemma":[0.0001260251,0.0001865395,0.003000874,0.00346229,0.0002106176,0.000425561,0.003366853,0.0001878451,0.0005580466,0.005335309,0.9830376,0.000102297],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0005689281,0.07560358,0.001235115,0.8729366,0.04747504,0.0001778033,0.0001049135,0.00002409621,0.001873911],"genre_scores_gemma":[0.01483565,0.1270229,0.005586225,0.7219957,0.1223641,0.0005005984,0.0002848484,0.00008986664,0.007320157],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.08103539,"threshold_uncertainty_score":0.4285612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03454154447542431,"score_gpt":0.3639646830667037,"score_spread":0.3294231385912794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}