{"id":"W2024039874","doi":"10.1158/1538-7445.am2014-ct411","title":"Abstract CT411: Immune profiling of patients vaccinated with the survivin targeted therapeutic vaccine DPX-Survivac demonstrates durable polyfunctional CD4+ and CD8+ T cells in ovarian cancer patients","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"","keywords":"Granzyme B; CD8; Immunology; Immune system; Cytotoxic T cell; Survivin; FOXP3; IL-2 receptor; Immunotherapy; Medicine; Cancer research; Ovarian cancer; ELISPOT; Ex vivo; T cell; Cancer; Biology; Internal medicine; In vivo; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001066123,0.0001330676,0.0002531243,0.000156415,0.0001240535,0.0002034619,0.00006886445,0.000236225,0.001578607],"category_scores_gemma":[0.0002194933,0.00008018643,0.0001380785,0.0001134569,0.0001068528,0.0001111623,0.00009152,0.000424735,0.0002314669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001120597,"about_ca_system_score_gemma":0.00008746771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004295627,"about_ca_topic_score_gemma":0.0002651623,"domain_scores_codex":[0.9999274,0.0000113546,0.000005286074,0.00002378413,0.00001088726,0.00002142151],"domain_scores_gemma":[0.9998813,0.00002672784,0.00002142389,0.00001094017,0.00001785862,0.00004171548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0217269,0.001776277,0.1390208,0.0001252323,0.00007102159,0.0006578478,0.0004919636,0.0006015683,0.798394,0.0001052968,0.0009272056,0.03610202],"study_design_scores_gemma":[0.0005132201,0.05418478,0.8200465,0.00002974484,0.000189854,0.002370029,0.0003989395,0.002151502,0.1134058,0.0001486479,0.006535,0.00002601149],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990926,0.0001378346,0.0001031611,0.00001628617,0.000005983325,0.00002173697,0.0001839439,0.00000543852,0.0004330487],"genre_scores_gemma":[0.9987993,0.00004819483,0.00006320095,0.00004744198,0.000006072394,0.00002389722,0.0003818203,0.000002897976,0.0006271307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001578607,"threshold_uncertainty_score":0.005280912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181541160724482,"score_gpt":0.2841180538733539,"score_spread":0.2659639378009057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}