{"id":"W2024055867","doi":"10.1038/ejhg.2015.56","title":"Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening. Summary and recommendations","year":2015,"lang":"en","type":"article","venue":"European Journal of Human Genetics","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Institute for Health and Care Research","keywords":"Prenatal screening; Aneuploidy; Prenatal diagnosis; Medicine; Genetic testing; Obstetrics; Genetics; Pregnancy; Biology; Fetus; Internal medicine; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04507652,0.001466586,0.001828669,0.003114184,0.001479844,0.007571345,0.004074497,0.01195254,0.01351042],"category_scores_gemma":[0.1252253,0.0006671307,0.001974006,0.002695961,0.0026948,0.01336453,0.005737753,0.01274698,0.004193947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006309789,"about_ca_system_score_gemma":0.03012488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01923826,"about_ca_topic_score_gemma":0.03223398,"domain_scores_codex":[0.9790166,0.00987457,0.002908052,0.001420045,0.005688739,0.001092018],"domain_scores_gemma":[0.8373204,0.1030318,0.007217154,0.003077874,0.04067998,0.008672859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001364113,0.00007996273,0.001426946,0.01165576,0.0001416669,0.0003371553,0.0008161237,0.0007715958,0.0001433283,0.03006268,0.603148,0.3512803],"study_design_scores_gemma":[0.00006629388,0.00009653709,0.002684763,0.06559728,0.0002583358,0.0005752848,0.003099727,0.0007579094,0.000244173,0.05751327,0.8689654,0.0001410316],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0002433841,0.1691606,0.002527311,0.8115084,0.01086076,0.0001153643,0.0003879853,0.00007313607,0.005123026],"genre_scores_gemma":[0.00962987,0.7391989,0.01929138,0.2090414,0.01289545,0.0004966948,0.0007816178,0.00007281495,0.008591842],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04507652,"threshold_uncertainty_score":0.2383903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08861825558215568,"score_gpt":0.311815821402719,"score_spread":0.2231975658205633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}