{"id":"W2024058161","doi":"10.2165/11537800-000000000-00000","title":"MicroRNA: Potential Targets for the Development of Novel Drugs?","year":2010,"lang":"en","type":"review","venue":"Drugs in R&D","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"microRNA; Biology; Epigenetics; Regulation of gene expression; Gene regulatory network; Gene expression; Translation (biology); Gene silencing; Computational biology; Gene; Messenger RNA; Cell biology; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000828415,0.0009956757,0.001818607,0.001060002,0.0003257437,0.001267959,0.001022307,0.002277682,0.0064257],"category_scores_gemma":[0.0006268182,0.0003516409,0.0004465531,0.0008928828,0.0009889939,0.002673517,0.0007263816,0.002499599,0.006813218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007324049,"about_ca_system_score_gemma":0.0006542179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002972296,"about_ca_topic_score_gemma":0.0006532678,"domain_scores_codex":[0.9997731,0.00006154284,0.00002122728,0.00004504254,0.00007406505,0.00002507487],"domain_scores_gemma":[0.9998264,0.00006253357,0.00002390139,0.0000122904,0.00004290539,0.00003199091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001962719,0.0001503392,0.0002099907,0.004782517,0.00007470629,0.0007017702,0.0001118322,0.0004375634,0.01306481,0.02338398,0.07136838,0.8855178],"study_design_scores_gemma":[0.00004673363,0.0001147865,0.0002057251,0.0005816378,0.00003199412,0.001407227,0.00004916985,0.000161929,0.001199775,0.00694069,0.9892418,0.00001855301],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002883596,0.9908367,0.001022674,0.003105471,0.001135322,0.00001509951,0.00003141764,0.00002948283,0.003535399],"genre_scores_gemma":[0.00291831,0.9873964,0.001784769,0.002261029,0.001153147,0.00004323742,0.0000682986,0.000009341131,0.004365485],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0064257,"threshold_uncertainty_score":0.02149612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01959533176365454,"score_gpt":0.3033970508526896,"score_spread":0.2838017190890351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}