{"id":"W2024069335","doi":"10.4161/chan.26734","title":"Structural aspects of calcium-release activated calcium channel function","year":2013,"lang":"en","type":"review","venue":"Channels","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"ORAI1; STIM1; Calmodulin; Cytosol; Chemistry; Calcium; Biophysics; Endoplasmic reticulum; Cell biology; Calcium signaling; Voltage-dependent calcium channel; Biochemistry; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001570891,0.0009618587,0.002205328,0.0005711231,0.0002665365,0.00009609029,0.0007592,0.0008374158,0.0009633481],"category_scores_gemma":[0.0003276957,0.0006915336,0.0009118826,0.001092605,0.000275721,0.0003495647,0.0002630711,0.0008546246,0.0006926049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001797327,"about_ca_system_score_gemma":0.0002745888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008919365,"about_ca_topic_score_gemma":7.208452e-7,"domain_scores_codex":[0.9958997,0.0003967645,0.001034832,0.001157029,0.0006448934,0.000866794],"domain_scores_gemma":[0.9975379,0.0003055732,0.001057919,0.0005515438,0.0001688251,0.0003782948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009028646,0.0003333564,1.104289e-7,0.03041545,0.0003052881,0.00008128298,0.0007628836,0.0002651748,0.0326167,0.002231284,0.008876992,0.9240212],"study_design_scores_gemma":[0.000825353,0.000549236,6.49343e-7,0.009073,0.0007288922,0.0001924913,0.0001268758,0.0007548169,0.2923101,0.001307193,0.6920258,0.002105598],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001505452,0.979583,0.0002082421,0.00004674966,0.01397357,0.002532695,0.0003191623,0.0002641389,0.001566976],"genre_scores_gemma":[0.05771463,0.9357125,0.000005585988,0.0001040416,0.002176711,0.0002775121,0.0001631642,0.0002163165,0.003629541],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9219156,"threshold_uncertainty_score":0.9999499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1446309215961706,"score_gpt":0.3401450215749872,"score_spread":0.1955140999788166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}