{"id":"W2024094969","doi":"10.1021/jo901080w","title":"Concerning the Hydrolytic Stability of 8-Aryl-2′-deoxyguanosine Nucleoside Adducts: Implications for Abasic Site Formation at Physiological pH","year":2009,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge; University of Guelph","funders":"","keywords":"Chemistry; Adduct; Aryl; Protonation; Nucleobase; Deoxyguanosine; AP site; Stereochemistry; Reactivity (psychology); Medicinal chemistry; Hydrolysis; Organic chemistry; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002542063,0.0003502606,0.0002207252,0.00008549378,0.00009851591,0.0002737773,0.0002544886,0.0003788146,0.001040798],"category_scores_gemma":[0.0004100261,0.00009047947,0.0001651251,0.00009943167,0.0002247024,0.0005090347,0.0001519426,0.0004052501,0.0002699333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001841993,"about_ca_system_score_gemma":0.00009702505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004813706,"about_ca_topic_score_gemma":0.0004616765,"domain_scores_codex":[0.9999136,0.00001407204,0.000003784651,0.00002650821,0.00002529103,0.0000167533],"domain_scores_gemma":[0.9998312,0.00006715711,0.00004274709,0.000009106635,0.00003461174,0.00001516769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000122597,0.00002127728,0.001240924,0.0001334379,0.00002128944,0.00007590401,0.00004880717,0.001005423,0.9930274,0.0003006371,0.00004228725,0.003959922],"study_design_scores_gemma":[0.000007235285,0.0005027595,0.01286647,0.00002088259,0.00002783147,0.0003369997,0.0001508177,0.008394999,0.9751759,0.0006761744,0.001815066,0.00002502849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834874,0.007748208,0.006188788,0.0001614405,0.00003416028,0.00001888749,0.0003513181,0.00004483698,0.001964915],"genre_scores_gemma":[0.996619,0.001735619,0.001003992,0.00002852927,0.000007967739,0.000008188284,0.0002163772,0.000005063048,0.0003753133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001040798,"threshold_uncertainty_score":0.003481805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01891347353092409,"score_gpt":0.2457029806107782,"score_spread":0.2267895070798541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}