{"id":"W2024110748","doi":"10.1002/hep.22354","title":"Proprotein convertase subtilisin/kexin type 9 (PCSK9)","year":2008,"lang":"en","type":"article","venue":"Hepatology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":400,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal","funders":"Canadian Institutes of Health Research; Pfizer Canada; McGill University; Pfizer","keywords":"Kexin; Proprotein convertase; PCSK9; Subtilisin; Hepatocyte; LDL receptor; Chemistry; Cell biology; Internal medicine; Endocrinology; Lipoprotein; Cholesterol; Biology; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002223237,0.0001524134,0.0005062012,0.00008747039,0.0001177911,0.000003247284,0.00007556245,0.0001963234,0.0005514518],"category_scores_gemma":[0.0001369376,0.0001245239,0.0001670558,0.0001845484,0.0001733454,0.00003892097,0.00003659424,0.0002569716,0.0007022792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006421885,"about_ca_system_score_gemma":0.000500847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008617322,"about_ca_topic_score_gemma":0.00006490503,"domain_scores_codex":[0.9986573,0.0001068379,0.0002546858,0.0003235013,0.0002744042,0.0003832025],"domain_scores_gemma":[0.998933,0.00001809258,0.00005204004,0.0006211751,0.0001582917,0.0002174439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001822776,0.000825859,0.8915895,0.0007995123,0.0006541079,0.01215075,0.0009722472,0.000001147035,0.006406644,0.003868991,0.03112715,0.04978132],"study_design_scores_gemma":[0.007445535,0.002110404,0.09042796,0.00009990644,0.0002683059,0.02542171,0.0001071867,0.0008747993,0.04731808,0.0004254416,0.8248411,0.0006595958],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990456,0.002288055,0.0001519192,0.001476334,0.000341367,0.0007208537,0.000003803411,0.0001283217,0.004433328],"genre_scores_gemma":[0.9950268,0.0003210792,0.0007667939,0.001893453,0.0002563377,0.00004646167,0.0000351297,0.00002897399,0.001625032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8011615,"threshold_uncertainty_score":0.9026612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03639240097985095,"score_gpt":0.2723162731558627,"score_spread":0.2359238721760117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}