{"id":"W2024119654","doi":"10.1159/000101306","title":"Role of Glycogen Synthase Kinase-3 in Cell Fate and Epithelial-Mesenchymal Transitions","year":2007,"lang":"en","type":"review","venue":"Cells Tissues Organs","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Epithelial–mesenchymal transition; Cell biology; Biology; GSK-3; Wnt signaling pathway; Adherens junction; Downregulation and upregulation; Cell fate determination; Snail; Signal transduction; Cadherin; Cell; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002166155,0.0003690698,0.000764825,0.0001587375,0.00004520883,0.00001659711,0.0002543334,0.0004738071,0.0001823518],"category_scores_gemma":[0.0000102688,0.0003487594,0.0001785522,0.0002298577,0.0001345775,0.000003687418,0.00008144448,0.0001640239,0.00002739677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000251404,"about_ca_system_score_gemma":0.0002045007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003559704,"about_ca_topic_score_gemma":0.00003550178,"domain_scores_codex":[0.9984167,0.00007380735,0.0005498664,0.0004901496,0.0001406918,0.0003288325],"domain_scores_gemma":[0.99932,0.00002714597,0.0001849797,0.0003096425,0.00005481331,0.0001034252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004454026,0.0002721635,0.0000318198,0.007759554,0.0002036494,0.00009583776,0.0007059922,0.000007983187,0.5712441,0.00001587955,0.0007583216,0.4188602],"study_design_scores_gemma":[0.0001892645,0.00006518289,0.000002646638,0.0008992372,0.0001619422,0.00001283622,0.00006656806,5.810309e-7,0.2940407,0.00001056947,0.7042335,0.0003168893],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007166859,0.9906215,0.00006235256,0.000006638799,0.0001283638,0.0004034567,0.0002650583,0.00001115159,0.001334626],"genre_scores_gemma":[0.006723058,0.9902375,0.0005546547,0.00001359315,0.0001794277,0.00003295822,0.0004678284,0.00007095894,0.001720018],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7034752,"threshold_uncertainty_score":0.9998965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01551539283827838,"score_gpt":0.2776806952680088,"score_spread":0.2621653024297304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}