{"id":"W2024134273","doi":"10.1371/journal.pone.0005856","title":"Intranasal Mucosal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances the Protection of BCG-Primed Guinea Pigs against Pulmonary Tuberculosis","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; McMaster University; McMaster University Medical Centre","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Public Health Service; National Institutes of Health; Institut National de la Santé et de la Recherche Médicale; Colorado State University","keywords":"Medicine; Tuberculosis vaccines; Tuberculosis; Immunology; Guinea pig; Nasal administration; Vaccination; BCG vaccine; Immunization; Spleen; Virology; Immune system; Mycobacterium tuberculosis; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000897487,0.0002767693,0.0007093446,0.0001988909,0.0001790832,0.00001919836,0.0002547078,0.000166993,0.0001436762],"category_scores_gemma":[0.001122943,0.0001734412,0.00009858675,0.0005185675,0.0001297016,0.0002202951,0.00004274803,0.0006256035,0.00001669457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009587721,"about_ca_system_score_gemma":0.0001271919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004140199,"about_ca_topic_score_gemma":0.0001460927,"domain_scores_codex":[0.9972683,0.0003962246,0.0005723275,0.000478929,0.0006707202,0.0006135412],"domain_scores_gemma":[0.9983656,0.0002425369,0.000201716,0.000588131,0.0003215479,0.0002804876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004807596,0.002527333,0.01365658,0.0002483732,0.0006620216,0.00005586892,0.000195351,0.00001461365,0.9590446,0.00002246345,0.0002713021,0.01849387],"study_design_scores_gemma":[0.002781918,0.008794252,0.6500119,0.0009931985,0.0006815071,0.000110905,0.0002965845,0.01308079,0.322451,0.000198186,0.0001456779,0.0004540914],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981041,0.0005475589,0.0001070397,0.01471777,0.00002051109,0.001340298,0.00001371618,0.0001274052,0.002084745],"genre_scores_gemma":[0.9954764,0.0004545985,0.002075843,0.001132631,0.0005004496,0.0001099257,0.00008730771,0.00003609788,0.0001267665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6365936,"threshold_uncertainty_score":0.7072728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04309146893197639,"score_gpt":0.2777897505171744,"score_spread":0.234698281585198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}