{"id":"W2024134273","doi":"10.1371/journal.pone.0005856","title":"Intranasal Mucosal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances the Protection of BCG-Primed Guinea Pigs against Pulmonary Tuberculosis","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; McMaster University; McMaster University Medical Centre","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Public Health Service; National Institutes of Health; Institut National de la Santé et de la Recherche Médicale; Colorado State University","keywords":"Medicine; Tuberculosis vaccines; Tuberculosis; Immunology; Guinea pig; Nasal administration; Vaccination; BCG vaccine; Immunization; Spleen; Virology; Immune system; Mycobacterium tuberculosis; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002874651,0.0005763032,0.0004259132,0.0002411728,0.000112575,0.0003464248,0.0002560677,0.0004961284,0.001277398],"category_scores_gemma":[0.0001947877,0.0002205965,0.000311684,0.00008408957,0.0003917278,0.0003057416,0.0001519323,0.001126724,0.0005404264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001698756,"about_ca_system_score_gemma":0.0002381765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002590861,"about_ca_topic_score_gemma":0.0004018375,"domain_scores_codex":[0.9998727,0.0000224677,0.000008841401,0.00002676148,0.00001436864,0.00005476906],"domain_scores_gemma":[0.999767,0.00005047267,0.00004834805,0.00003092446,0.00001689109,0.00008631969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008065736,0.0005359878,0.0002903607,0.00007393031,0.000006340778,0.00007565804,0.0000367482,0.00005560074,0.9956015,0.00003844693,0.00007300456,0.00240591],"study_design_scores_gemma":[0.0003311526,0.02698155,0.01160086,0.00006591477,0.00008275674,0.000647908,0.0001006077,0.0009101731,0.9569094,0.00008206716,0.002274982,0.00001266736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969999,0.0009438345,0.0007442425,0.0001399028,0.00008007115,0.00005161737,0.00009498308,0.0000926067,0.0008528092],"genre_scores_gemma":[0.9956151,0.0007399103,0.001164235,0.0001291961,0.00004234193,0.00005840484,0.0002412231,0.00002348521,0.001985985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001277398,"threshold_uncertainty_score":0.004273295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04309146893197639,"score_gpt":0.2777897505171744,"score_spread":0.234698281585198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}