{"id":"W2024148072","doi":"10.1038/sj.cgt.7700466","title":"Intratumoral coinjection of two adenoviral vectors expressing functional interleukin-18 and inducible protein-10, respectively, synergizes to facilitate regression of established tumors","year":2002,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Cancer research; CD8; Cytotoxic T cell; Immunotherapy; Cytokine; Genetic enhancement; Tumor necrosis factor alpha; Viral vector; Tumor microenvironment; Chemokine; Biology; T cell; Interleukin 2; Immune system; Immunology; Recombinant DNA; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002744412,0.0002699355,0.0004719875,0.0003165459,0.0001788214,0.00002118162,0.000176883,0.0001396091,0.00249687],"category_scores_gemma":[0.00005623491,0.00021571,0.00009951081,0.0003503054,0.0003755668,0.0002345836,0.00005633138,0.0002472525,0.00001336894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009821841,"about_ca_system_score_gemma":0.0000984344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005567173,"about_ca_topic_score_gemma":0.00001551902,"domain_scores_codex":[0.998358,0.0003839344,0.0004701549,0.0003915334,0.00008513322,0.0003113189],"domain_scores_gemma":[0.9990982,0.0000921887,0.0002838751,0.0003134099,0.0001842892,0.0000280342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006778283,0.0001349853,0.0006146135,0.00002269023,0.0001894106,0.000001711198,0.00303404,0.00005659921,0.9678135,0.00003880925,0.001250636,0.02006475],"study_design_scores_gemma":[0.002942121,0.001322941,0.008429545,0.0003006064,0.00001288743,0.00002857634,0.0004745174,0.000006270662,0.9823763,0.00009257713,0.003789022,0.0002246038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686501,0.02984091,0.0001384409,0.0001054293,0.0005104161,0.0004403192,0.00005080854,0.00004362209,0.0002199588],"genre_scores_gemma":[0.9938561,0.000743438,0.0001300199,0.00005265412,0.00004898352,0.0001078752,0.00001563783,0.00002931801,0.005015955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02909747,"threshold_uncertainty_score":0.998415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07241367648858245,"score_gpt":0.2804831563346636,"score_spread":0.2080694798460812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}