{"id":"W2024206073","doi":"10.1007/s00432-012-1235-x","title":"Triptolide triggers the apoptosis of pancreatic cancer cells via the downregulation of Decoy receptor 3 expression","year":2012,"lang":"en","type":"article","venue":"Journal of Cancer Research and Clinical Oncology","topic":"Natural Compounds in Disease Treatment","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Public Health Agency of Canada","keywords":"Triptolide; Apoptosis; Pancreatic cancer; Cancer research; Downregulation and upregulation; Gemcitabine; Chemistry; Cancer cell; Flow cytometry; In vivo; Cancer; Biology; Medicine; Molecular biology; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007013592,0.0001811574,0.0002684862,0.0001787205,0.0001373922,0.0002444446,0.0001526772,0.0002568981,0.002047861],"category_scores_gemma":[0.0001187299,0.0001026583,0.0002798871,0.0001450451,0.000175817,0.0002140981,0.0001849737,0.0007545746,0.0003222527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002950797,"about_ca_system_score_gemma":0.0002721645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003410173,"about_ca_topic_score_gemma":0.0005729391,"domain_scores_codex":[0.9998977,0.00001702106,0.00001019669,0.00001389787,0.00002742106,0.00003370423],"domain_scores_gemma":[0.9999436,0.00001420046,0.00001636787,0.000007859458,0.000006964408,0.00001109668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006011329,0.00005144139,0.0003073621,0.0000923613,0.00001640502,0.0001892447,0.00002512354,0.00008368838,0.9935874,0.0002031502,0.000286004,0.004556659],"study_design_scores_gemma":[0.0001508749,0.001101276,0.007226316,0.00001242775,0.00004326986,0.0008624896,0.0000836462,0.0009223024,0.9853753,0.000249749,0.003963493,0.000009033961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925653,0.002541973,0.001583095,0.0003004063,0.0000609343,0.00003810662,0.0004044414,0.00007129338,0.002434325],"genre_scores_gemma":[0.9953693,0.001356313,0.0006788493,0.0001145199,0.00002025786,0.00004480989,0.0004853029,0.000007631646,0.001922939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002047861,"threshold_uncertainty_score":0.006850779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1455508759927197,"score_gpt":0.530487809402786,"score_spread":0.3849369334100663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}