{"id":"W2024206888","doi":"10.1007/s40256-013-0018-3","title":"Pharmacokinetics and Pharmacodynamics of the Antiplatelet Combination Aspirin (Acetylsalicylic Acid) Plus Extended-Release Dipyridamole Are Not Altered by Coadministration with the Potent CYP2C19 Inhibitor Omeprazole","year":2013,"lang":"en","type":"article","venue":"American Journal of Cardiovascular Drugs","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Celerion (Canada)","funders":"","keywords":"Omeprazole; Medicine; Proton-pump inhibitor; Pharmacology; Pharmacodynamics; Pharmacokinetics; Dipyridamole; Aspirin; Drug interaction; CYP2C19; Crossover study; Clopidogrel; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001889545,0.0002247183,0.0004922642,0.000142269,0.0001499046,0.0003395506,0.0001466058,0.0002742276,0.0009043244],"category_scores_gemma":[0.001180083,0.0002672847,0.0003773067,0.0001663722,0.0002711786,0.0004223106,0.0001040947,0.000749224,0.0002373185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002863549,"about_ca_system_score_gemma":0.0002193159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007098439,"about_ca_topic_score_gemma":0.001265237,"domain_scores_codex":[0.9997328,0.0000921429,0.00001704937,0.00004788291,0.00007414843,0.00003596152],"domain_scores_gemma":[0.9996455,0.00009326875,0.0001046061,0.00005547741,0.00001627883,0.00008476868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1996747,0.002790416,0.09333362,0.0001528694,0.001654423,0.001815519,0.0003606146,0.001841777,0.5318453,0.0004278636,0.001580597,0.1645223],"study_design_scores_gemma":[0.007367901,0.07368723,0.8078721,0.00002100243,0.001321139,0.006340277,0.0001643004,0.00789473,0.08910333,0.0003080471,0.005842366,0.0000775242],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988212,0.0004277318,0.0002029579,0.00004744628,0.00001649716,0.00000868133,0.00007071012,0.00001584525,0.0003889092],"genre_scores_gemma":[0.9993016,0.0001306691,0.000146454,0.00003020403,0.00002200565,0.000004141965,0.0001273106,0.000006552463,0.000231163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009043244,"threshold_uncertainty_score":0.003025234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004512241784459435,"score_gpt":0.2175551910978554,"score_spread":0.2130429493133959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}