{"id":"W2024248286","doi":"10.1016/j.febslet.2005.07.017","title":"Sodium channel activators: Model of binding inside the pore and a possible mechanism of action","year":2005,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Veratridine; Batrachotoxin; Sodium channel; Chemistry; Activator (genetics); Biophysics; Allosteric regulation; Selectivity; Ion channel; Ligand-gated ion channel; Mechanism of action; Sodium; Biochemistry; Enzyme; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003538115,0.0007885203,0.00130394,0.0005772669,0.001250039,0.001414432,0.002562501,0.002836786,0.005474376],"category_scores_gemma":[0.0003911529,0.0004520016,0.000968135,0.0003604307,0.002156022,0.00317784,0.0008016755,0.001196988,0.002523352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008970188,"about_ca_system_score_gemma":0.0009285401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005305735,"about_ca_topic_score_gemma":0.0002460263,"domain_scores_codex":[0.9997167,0.00005271945,0.0000107214,0.00007309968,0.00007587273,0.00007081348],"domain_scores_gemma":[0.9998467,0.00004393628,0.00002014204,0.00001597519,0.00002739336,0.00004586659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003483022,0.0001361415,0.0003126731,0.0005396652,0.00003227441,0.001888711,0.0003719768,0.02390114,0.1430078,0.8211952,0.002590682,0.005675394],"study_design_scores_gemma":[0.0004385631,0.001051731,0.0004014719,0.00007181656,0.00007834533,0.00182489,0.000384183,0.3673992,0.04775307,0.5580448,0.0224587,0.00009322612],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2288479,0.0153493,0.6134906,0.02062803,0.002808376,0.00057335,0.0004912558,0.002845526,0.1149657],"genre_scores_gemma":[0.8891016,0.0069739,0.06246684,0.001394152,0.0006167674,0.0005466785,0.00014095,0.0001491164,0.03860999],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005474376,"threshold_uncertainty_score":0.01831365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02331491618678704,"score_gpt":0.2404340886970013,"score_spread":0.2171191725102142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}