{"id":"W2024248286","doi":"10.1016/j.febslet.2005.07.017","title":"Sodium channel activators: Model of binding inside the pore and a possible mechanism of action","year":2005,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Veratridine; Batrachotoxin; Sodium channel; Chemistry; Activator (genetics); Biophysics; Allosteric regulation; Selectivity; Ion channel; Ligand-gated ion channel; Mechanism of action; Sodium; Biochemistry; Enzyme; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009455504,0.00007068708,0.00007264737,0.00004906831,0.00005139489,0.000006273412,0.00004957136,0.0000690807,0.000003995407],"category_scores_gemma":[0.00001318415,0.000055222,0.00004183064,0.00005224432,0.00004229777,0.00000887793,0.00003216423,0.00004477879,6.694206e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009347019,"about_ca_system_score_gemma":0.00001516581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009270449,"about_ca_topic_score_gemma":0.000005394075,"domain_scores_codex":[0.9995629,0.00001945665,0.0001213762,0.0001222191,0.00008563197,0.00008844216],"domain_scores_gemma":[0.9997186,0.00000514826,0.0001033065,0.0001195454,0.0000314342,0.00002193359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000610862,0.00001422793,0.00002862124,0.00001262441,0.0000193214,7.701161e-8,0.0001739695,0.002248293,0.995504,0.0002145795,0.0008639466,0.0008592986],"study_design_scores_gemma":[0.0002965123,0.00005098054,0.000109279,0.00001046542,0.00001045334,0.000005397625,0.0001865956,0.02216429,0.9765117,0.00009219858,0.0004943328,0.00006784256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801911,0.00002429122,0.01717012,0.00225163,0.000128209,0.00009183406,0.000007188469,0.000005752257,0.0001298543],"genre_scores_gemma":[0.9985943,0.00002432717,0.0002774181,0.0006794924,0.0002091307,0.000005795989,0.00002456881,0.000009128832,0.0001758763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01991599,"threshold_uncertainty_score":0.2251888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02331491618678704,"score_gpt":0.2404340886970013,"score_spread":0.2171191725102142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}