{"id":"W2024269867","doi":"10.1007/s00401-013-1236-0","title":"CSF Apo-E levels associate with cognitive decline and MRI changes","year":2014,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research","keywords":"Apolipoprotein E; Cerebrospinal fluid; Internal medicine; Endocrinology; Alzheimer's Disease Neuroimaging Initiative; Cognitive decline; Biomarker; Psychology; Allele; Alzheimer's disease; Dementia; Medicine; Biology; Disease; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002141588,0.000187654,0.0002955485,0.00006342826,0.0001298628,0.00003409198,0.00006450987,0.00006483828,0.00007164984],"category_scores_gemma":[0.0004772732,0.0001166447,0.00003646804,0.0001224966,0.0001824249,0.000061435,0.0001212092,0.0001912379,0.00006394397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001346817,"about_ca_system_score_gemma":0.00003554786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004715212,"about_ca_topic_score_gemma":0.000006700213,"domain_scores_codex":[0.9986335,0.000207139,0.0001029263,0.0003938452,0.0002941464,0.0003684502],"domain_scores_gemma":[0.9990136,0.0002772841,0.0000744908,0.0001896966,0.0001399179,0.0003049919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003037036,0.001840648,0.9282339,0.0001272135,0.002406017,0.009117974,0.0003802091,2.675143e-7,0.006165106,0.0001393666,0.0006905883,0.04786167],"study_design_scores_gemma":[0.00290107,0.003388889,0.9899496,0.00006923649,0.0004609878,0.0003356203,0.00004405207,0.00003539586,0.001622487,0.0001684408,0.0008682935,0.0001559645],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990263,0.000504613,0.0000383347,0.004187649,0.00002338459,0.0004064465,0.0000620848,0.0000994886,0.004414998],"genre_scores_gemma":[0.9967878,0.0003069293,0.0002265664,0.002340175,0.00009403851,0.00004184092,0.00004030303,0.00002549331,0.0001368761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06171566,"threshold_uncertainty_score":0.4756634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04128621202777131,"score_gpt":0.3099468987930626,"score_spread":0.2686606867652913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}