{"id":"W2024284445","doi":"10.1158/1538-7445.am2012-lb-214","title":"Abstract LB-214: Interim results from a randomized Phase 1-2 first-in-human (FIH) study of PK/PD guided escalating doses of SGI-110, a novel subcutaneous (SQ) second generation hypomethylating agent (HMA) in relapsed/refractory MDS and AML","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Decitabine; Medicine; Tolerability; Neutropenia; Adverse effect; Pharmacology; Phases of clinical research; Oncology; Internal medicine; Hypomethylating agent; Lethargy; Clinical trial; Toxicity; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005410042,0.001980065,0.002750578,0.0005463572,0.0007130071,0.001466444,0.0009941999,0.001996575,0.005343654],"category_scores_gemma":[0.002043854,0.0007210163,0.001750893,0.0003808365,0.001101192,0.001073588,0.0005895902,0.003650979,0.001719533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001095767,"about_ca_system_score_gemma":0.002289458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007446177,"about_ca_topic_score_gemma":0.001516047,"domain_scores_codex":[0.998582,0.00089145,0.00006860516,0.0001165498,0.0001304121,0.0002109338],"domain_scores_gemma":[0.9985788,0.0002759261,0.0002459653,0.0001631787,0.0001005428,0.0006355605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8696861,0.03668458,0.003406226,0.0006576044,0.0013491,0.0002124053,0.0001147823,0.001480674,0.02339259,0.0004217662,0.01102121,0.05157287],"study_design_scores_gemma":[0.6312314,0.3482431,0.007631201,0.00005813577,0.0006796214,0.0001882612,0.00003254957,0.001087299,0.004379911,0.0004818982,0.005948325,0.0000382618],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9539225,0.003881254,0.003071124,0.002523354,0.0008425165,0.01495272,0.01202824,0.0006829042,0.008095316],"genre_scores_gemma":[0.9161494,0.003126377,0.01146519,0.006790263,0.0009134438,0.01845227,0.02486194,0.0002728905,0.0179683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005410042,"threshold_uncertainty_score":0.02861142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1592843577178699,"score_gpt":0.4433153469677062,"score_spread":0.2840309892498363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}