{"id":"W2024301757","doi":"10.1016/j.neuron.2009.01.017","title":"An Unbiased Expression Screen for Synaptogenic Proteins Identifies the LRRTM Protein Family as Synaptic Organizers","year":2009,"lang":"en","type":"article","venue":"Neuron","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":361,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institutes of Health; Michael Smith Health Research BC; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre","keywords":"Neuroligin; Biology; Synapse; Postsynaptic potential; Neuroscience; Cell biology; Synaptogenesis; Transmembrane protein; Excitatory postsynaptic potential; Genetics; Inhibitory postsynaptic potential","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002527804,0.0004252464,0.0003332105,0.0005449171,0.0004761377,0.0004384337,0.0003277402,0.0003234948,0.0009168657],"category_scores_gemma":[0.0002541462,0.0001876693,0.0002466518,0.0004255153,0.0002153605,0.0001794263,0.0004805241,0.0003387964,0.0005666837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002823402,"about_ca_system_score_gemma":0.0002274021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006864704,"about_ca_topic_score_gemma":0.002447475,"domain_scores_codex":[0.9997618,0.00002929639,0.00001839798,0.00004075077,0.00009958771,0.00005018265],"domain_scores_gemma":[0.9998635,0.00003854838,0.0000294605,0.00002215259,0.0000232487,0.00002305157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004141135,0.000009400105,0.0003717575,0.00001277002,0.000004890427,0.00007697615,0.000007102471,0.00002426092,0.9982302,0.00006165608,0.00005388704,0.001105764],"study_design_scores_gemma":[0.00001640536,0.000161089,0.01575112,0.000005959835,0.00009523929,0.001256772,0.00007447545,0.001167333,0.9763286,0.0001036956,0.005031047,0.000008318314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837171,0.001554327,0.01026682,0.0001895889,0.0000220549,0.0000686635,0.001670818,0.0001264154,0.002384214],"genre_scores_gemma":[0.9767146,0.00184488,0.0116535,0.0002183871,0.00002068295,0.00006913839,0.004630133,0.0001050986,0.004743516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009168657,"threshold_uncertainty_score":0.003067255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05346741938559599,"score_gpt":0.3469518236467135,"score_spread":0.2934844042611174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}