{"id":"W2024313189","doi":"10.1002/ajmg.b.31109","title":"Maternal smoking during pregnancy is associated with epigenetic modifications of the brain‐derived neurotrophic factor‐6 exon in adolescent offspring","year":2010,"lang":"en","type":"article","venue":"American Journal of Medical Genetics Part B Neuropsychiatric Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Université du Québec à Chicoutimi; Dawson College; Cegep de Thetford; Université de Montréal; Cegep de Trois-Rivieres; Cégep de Jonquière; McGill University; SickKids Foundation; University of Toronto; Montreal Neurological Institute and Hospital","funders":"National Institute of Mental Health; Canadian Institutes of Health Research","keywords":"DNA methylation; Epigenetics; Offspring; Neurotrophic factors; Brain-derived neurotrophic factor; Exon; In utero; Methylation; Biology; Bisulfite sequencing; Pregnancy; Endocrinology; Internal medicine; Genetics; Medicine; Gene; Gene expression; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043306,0.0001496665,0.000166413,0.000273906,0.0001252917,0.0001816987,0.00009622217,0.0002011875,0.001000563],"category_scores_gemma":[0.000400223,0.000189054,0.0001260546,0.0001326051,0.0001727288,0.0000630994,0.0001478771,0.0003300353,0.0001080533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009537207,"about_ca_system_score_gemma":0.0001350753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001866773,"about_ca_topic_score_gemma":0.002154055,"domain_scores_codex":[0.9999059,0.0000216871,0.000006071132,0.00002637383,0.00002219172,0.00001769207],"domain_scores_gemma":[0.9997523,0.00004521384,0.0001209201,0.00001684693,0.0000208177,0.00004376709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001238548,0.0001993288,0.7427549,0.00004495722,0.0001304913,0.001513033,0.0008778967,0.00006023944,0.2391006,0.0001702206,0.0001622036,0.01374754],"study_design_scores_gemma":[0.000006113389,0.0001439214,0.9904799,0.000007540905,0.00004250893,0.001008472,0.0001019042,0.0001152045,0.007808738,0.0000438216,0.0002386768,0.000003238907],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995623,0.0001353151,0.0001072899,0.000022447,0.000002742154,0.000001166204,0.00003743853,0.000003212689,0.0001280261],"genre_scores_gemma":[0.9990848,0.0002641708,0.0001496425,0.00001482643,0.000002849405,0.000004937709,0.00006170321,0.000003976262,0.0004129829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001866773,"threshold_uncertainty_score":0.00371176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01476283571690024,"score_gpt":0.2598784530507639,"score_spread":0.2451156173338637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}