{"id":"W2024337137","doi":"10.1016/j.neuroscience.2010.05.031","title":"Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease","year":2010,"lang":"en","type":"article","venue":"Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Western University; Lawson Health Research Institute","funders":"Canadian Institutes of Health Research; Bayer Canada","keywords":"Neuroprotection; Amyloid precursor protein; Estrogen; Alzheimer's disease; Disease; Genetically modified mouse; Endocrinology; Internal medicine; Amyloid (mycology); Amyloid beta; Amyloid precursor protein secretase; Transgene; Neuroscience; Biology; Medicine; Biochemistry; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002123989,0.0003362503,0.0003286501,0.0005544635,0.0003139365,0.0003581396,0.0002520007,0.000273823,0.001068],"category_scores_gemma":[0.0001970781,0.000160409,0.0002068455,0.0001868346,0.0005392131,0.0003873727,0.000207167,0.000432996,0.0001618963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003598761,"about_ca_system_score_gemma":0.0004158324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004429714,"about_ca_topic_score_gemma":0.0005871883,"domain_scores_codex":[0.9999375,0.000013145,0.000005972889,0.000007566535,0.00001410578,0.00002169937],"domain_scores_gemma":[0.9998934,0.00001372175,0.00002878407,0.00001300913,0.00002362697,0.00002746496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004405705,0.0002350011,0.004170548,0.0003761264,0.00008519524,0.001942286,0.0001654442,0.0003049714,0.9502206,0.01047089,0.000467844,0.02715536],"study_design_scores_gemma":[0.0006551408,0.003190845,0.1183325,0.0001655167,0.0004465525,0.006023304,0.0007760833,0.0006734239,0.8259369,0.02256203,0.02118486,0.00005293672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9542037,0.03672364,0.001134754,0.00131373,0.0001847963,0.00001421297,0.0002591905,0.0000538833,0.006112091],"genre_scores_gemma":[0.9818419,0.01572043,0.0005500995,0.0001624383,0.0000904597,0.00001208861,0.0001409692,0.000006517652,0.00147513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001068,"threshold_uncertainty_score":0.003572822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04041417993606059,"score_gpt":0.3037011438092521,"score_spread":0.2632869638731914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}