{"id":"W2024389323","doi":"10.1016/j.bmcl.2005.11.076","title":"Triaminotriazine DNA helicase inhibitors with antibacterial activity","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Cytotoxicity; Helicase; Antibacterial activity; DNA; Antibacterial agent; Pseudomonas aeruginosa; dnaB helicase; Mode of action; Mechanism of action; Antibiotics; Biochemistry; In vitro; Bacteria; RNA; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002357415,0.0006386876,0.0005164108,0.000382621,0.0002284426,0.000306032,0.0004929031,0.0004572373,0.004681107],"category_scores_gemma":[0.0002000163,0.0002704165,0.0002528787,0.000313716,0.0001720868,0.0002294568,0.0002535716,0.0009353315,0.001267536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000303004,"about_ca_system_score_gemma":0.0002546296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007557055,"about_ca_topic_score_gemma":0.001426592,"domain_scores_codex":[0.9998597,0.00002015111,0.00001514543,0.0000221535,0.00003846583,0.00004431939],"domain_scores_gemma":[0.999879,0.00001904693,0.00003063531,0.00001615459,0.00001731646,0.00003787865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008115881,0.0001876853,0.0001711086,0.0001831342,0.00004620855,0.0003246866,0.00004003642,0.0005343988,0.9746557,0.0006610821,0.001467541,0.02091682],"study_design_scores_gemma":[0.0006019126,0.003313785,0.001714585,0.00002784155,0.0001219325,0.001768998,0.0000190902,0.001202144,0.9673082,0.0001293788,0.02376559,0.0000265098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9417445,0.02282982,0.006656955,0.0008570997,0.0003977744,0.000321091,0.001050272,0.0009449447,0.02519758],"genre_scores_gemma":[0.9643873,0.01298204,0.003413134,0.0004443143,0.000127922,0.0002121396,0.001826902,0.00005754298,0.01654874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004681107,"threshold_uncertainty_score":0.01565987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005183815270924777,"score_gpt":0.2071175070123641,"score_spread":0.2019336917414393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}