{"id":"W2024389323","doi":"10.1016/j.bmcl.2005.11.076","title":"Triaminotriazine DNA helicase inhibitors with antibacterial activity","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Cytotoxicity; Helicase; Antibacterial activity; DNA; Antibacterial agent; Pseudomonas aeruginosa; dnaB helicase; Mode of action; Mechanism of action; Antibiotics; Biochemistry; In vitro; Bacteria; RNA; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001813307,0.0004143908,0.0003330315,0.00002311846,0.0001140238,0.00003508665,0.0003616191,0.0002777964,0.0002925831],"category_scores_gemma":[0.00009924801,0.0003540095,0.0001234714,0.0001646831,0.000316061,0.0000133833,0.0001246934,0.000274409,0.00003362349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007835863,"about_ca_system_score_gemma":0.0001366303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007100281,"about_ca_topic_score_gemma":0.000002305306,"domain_scores_codex":[0.9980569,0.00002977423,0.0003153798,0.0006970887,0.0003824858,0.0005183269],"domain_scores_gemma":[0.9987901,0.00001693401,0.0001954297,0.0006290922,0.00006043786,0.0003079722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007107735,0.0001522491,0.0002720182,0.00006236097,0.00009467237,0.00004884731,0.00003033736,0.000001246391,0.9853659,2.530532e-7,0.01106974,0.002191613],"study_design_scores_gemma":[0.002614123,0.00012014,0.0003499467,0.00004656795,0.00007756019,0.0003330242,0.00004812636,0.000005826461,0.9545468,3.511307e-7,0.04142606,0.000431487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947084,0.0001680055,0.0002142191,0.003770422,0.0001699387,0.0001471103,0.00002892485,0.00006356701,0.0007294237],"genre_scores_gemma":[0.9927106,0.00004755365,0.0003026352,0.001046863,0.005071206,0.00001315973,0.0001821869,0.00006332045,0.0005624562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0308191,"threshold_uncertainty_score":0.9998912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005183815270924777,"score_gpt":0.2071175070123641,"score_spread":0.2019336917414393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}