{"id":"W2024399113","doi":"10.1593/neo.06283","title":"Three-Color FISH Analysis of TMPRSS2/ERG Fusions in Prostate Cancer Indicates That Genomic Microdeletion of Chromosome 21 Is Associated with Rearrangement","year":2006,"lang":"en","type":"article","venue":"Neoplasia","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":186,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"TMPRSS2; Fusion gene; Biology; Fluorescence in situ hybridization; Erg; Chromosomal translocation; Fusion transcript; Molecular biology; Gene rearrangement; Chimeric gene; Chromosomal rearrangement; Cancer research; Genetics; Breakpoint; Gene; Karyotype; Chromosome; Pathology; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000166042,0.0001618718,0.0005549398,0.0005562594,0.00004670932,0.000008969246,0.0000862759,0.00009028779,0.0003938681],"category_scores_gemma":[0.00001094985,0.000118605,0.0001179944,0.001287222,0.0001358177,0.00005316487,0.00003837893,0.0001465618,0.000002990399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003840155,"about_ca_system_score_gemma":0.0002583765,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00540907,"about_ca_topic_score_gemma":0.02296968,"domain_scores_codex":[0.9986207,0.00003281789,0.0003356584,0.0002953203,0.000402594,0.0003129319],"domain_scores_gemma":[0.9992596,0.00005075686,0.0002556474,0.0002164962,0.0001545218,0.00006301063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006967924,0.000483982,0.8885686,0.00008869958,0.001131079,0.00004295792,0.0007639156,0.000221882,0.1062418,0.00000526648,0.001043971,0.0007110484],"study_design_scores_gemma":[0.003363484,0.0003848005,0.9429384,0.0002227529,0.00107006,0.00000220427,0.0001118813,0.0006857537,0.05088312,0.00002108501,0.0002064586,0.0001099482],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963863,0.000777719,0.000004506216,0.001262975,0.00002468466,0.0007621671,0.000430405,0.00001854402,0.0003326599],"genre_scores_gemma":[0.9977117,0.000611331,0.00008611411,0.00006014977,0.00001972452,0.000135121,0.0005803199,0.00002080492,0.0007747958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05535864,"threshold_uncertainty_score":0.9948586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01698011405250232,"score_gpt":0.2733154797476255,"score_spread":0.2563353656951232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}