{"id":"W2024401137","doi":"10.1074/jbc.m110.116293","title":"Roles of Fragile X Mental Retardation Protein in Dopaminergic Stimulation-induced Synapse-associated Protein Synthesis and Subsequent α-Amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) Receptor Internalization","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Internalization; AMPA receptor; FMR1; Cell biology; Biology; Receptor; Synaptic plasticity; Dendritic spine; NMDA receptor; Neuroscience; Biochemistry; Hippocampal formation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117685,0.0005293236,0.0001413108,0.0002037216,0.0001966771,0.0001869331,0.0001349843,0.0003832874,0.0008504692],"category_scores_gemma":[0.00008918598,0.0001313087,0.0004875731,0.00006944855,0.0003040139,0.0002511863,0.0001975173,0.0004543248,0.0002600679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003462133,"about_ca_system_score_gemma":0.0002001066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001024558,"about_ca_topic_score_gemma":0.0008405241,"domain_scores_codex":[0.9999275,0.00001099267,0.000007657834,0.00001978702,0.00001435973,0.0000197995],"domain_scores_gemma":[0.9999214,0.000007425127,0.00003406398,0.000006781538,0.000008120976,0.00002210434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002751903,0.00002626697,0.0004620687,0.00005744207,0.00001211029,0.0004621617,0.00003647395,0.00003371523,0.9972124,0.0002121697,0.00004202812,0.001168101],"study_design_scores_gemma":[0.00006551023,0.0008100547,0.0888376,0.00003597773,0.00008805501,0.003542377,0.0001553458,0.001055305,0.9017965,0.000300383,0.003290284,0.00002264102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943606,0.003276354,0.0009452628,0.000147805,0.00002330716,0.00001296325,0.0002178658,0.00005043649,0.0009654033],"genre_scores_gemma":[0.9960743,0.001301583,0.0007743829,0.00004419125,0.0000063781,0.00002336882,0.0001923794,0.000007307376,0.001576036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001024558,"threshold_uncertainty_score":0.002845109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01224512559820081,"score_gpt":0.232716490796732,"score_spread":0.2204713651985311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}